Method and apparatus for providing stable voltage to analytical system

• US 8,030,942 B2
• Filed: 11/08/2007
• Issued: 10/04/2011
• Est. Priority Date: 04/15/2005
• Status: Active Grant

• Current Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Original Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Inventors: Diamond, Steven, Wei, Baoguo, Forest, Martin
• Primary Examiner(s): Nguyen; Vincent Q
• Application Number:
  US11/937,196
• Publication Number:
  US 20080073224A1
• Time in Patent Office: 1,426 Days
• Field of Search: 324/73.1, 324/444, 324/71.1, 204/224.M
• US Class Current: 324/444
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875

Abstract

An electrochemical cell has two terminals. One of the terminals is connected to a pulse-width-modulated (PWM) power supply and to a voltmeter. The other terminal is connected to circuitry capable of switching between amperometric and potentiometric measurement modes. A sequence of successive approximations permits selection of a PWM duty cycle giving rise to a desired voltage at the terminal connected with the power supply. In this way a stable excitation voltage is supplied to the cell even in the face of supply voltage instability or drift or instability in electronics coupled with the cell.

Claims

1. A method for maintaining a desired excitation voltage from a potentially unstable voltage source to a first electrode of an electrochemical cell comprising first and second electrodes, said method comprising the steps of:

(a) performing a calibration step comprising applying an excitation voltage from the voltage source to the first and second electrodes in each of a plurality of successive steps to arrive by successive approximation at a digital control signal for the voltage source that produces the desired voltage to be applied to the electrodes; and

(b) applying the digital control signal to the voltage source to maintain the excitation voltage at the desired level.

2. A method for electrochemical measurement of an analyte in a sample comprising the steps of:

(a) calibrating an electrochemical device comprising a potentially unstable voltage source and first and second electrodes of an electrochemical cell, said calibration step comprising applying an excitation voltage from the voltage source to the first and second electrodes in each of a plurality of successive steps to arrive by successive approximation at a digital control signal for the voltage source that produces a desired voltage to be applied to the electrodes;

(b) introducing the sample into the electrochemical cell;

(c) applying the desired voltage to the first electrode using the digital control signal determined in step (a); and

(d) measuring current between the electrodes as an indication of the amount of analyte in the sample.

3. The method of claim 2, further comprising a recalibration step performed after step (b) and before step (d), said recalibration step comprising the steps of applying an excitation voltage from the voltage source to the first and second electrodes in each of a plurality of successive steps to arrive by successive approximation at an updated digital control signal for the voltage source that produces the desired voltage to be applied to the electrodes in the presence of the sample and using the updated digital control signal to apply voltage for measurement of current in step (d).

4. The method of claim 3, wherein the sample is a liquid sample.