Methods and systems for tissue analysis
First Claim
Patent Images
1. A method of analyzing tissue, comprising:
- illuminating a tissue with at least one of a coherent light or a partially coherent light;
receiving a further light reflected from the tissue and forming a series of speckle patterns; and
analyzing changes in the speckle patterns at time intervals sufficient to measure changes caused by a microscopic motion of objects within the tissue, wherein the tissue is at least one of in vivo or an internal tissue.
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Abstract
The invention relates to methods and systems to optically analyze samples such as tissue based on speckle patterns of microscopic motion, such as Brownian motion.
252 Citations
23 Claims
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1. A method of analyzing tissue, comprising:
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illuminating a tissue with at least one of a coherent light or a partially coherent light; receiving a further light reflected from the tissue and forming a series of speckle patterns; and analyzing changes in the speckle patterns at time intervals sufficient to measure changes caused by a microscopic motion of objects within the tissue, wherein the tissue is at least one of in vivo or an internal tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of analyzing a tissue structure, comprising:
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illuminating a tissue with at least one of a coherent light or a partially coherent light; receiving a further light reflected from the tissue and forming a series of speckle patterns; and obtaining speckle pattern data at time intervals sufficient to measure a microscopic motion within the tissue structure or with a tissue adjacent to the structure; and assessing the tissue structure by analyzing spatial characteristics of the speckle pattern data to determine at least one of structural characteristics or biomechanical characteristics of the tissue structure, wherein the tissue structure is at least one of in vivo or an internal tissue structure. - View Dependent Claims (14, 15)
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16. An apparatus for analyzing tissue, comprising:
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a first arrangement configured to illuminate a tissue with at least one of a coherent light or a partially coherent light; a second arrangement configured to receive a further light reflected from the tissue and form a series of speckle patterns; and a third arrangement configured to analyze changes in the speckle patterns at time intervals sufficient to measure changes caused by a microscopic motion of objects within the tissue, wherein the tissue is at least one of in vivo or an internal tissue. - View Dependent Claims (17, 18, 19)
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20. An apparatus for analyzing a tissue structure, comprising:
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a first arrangement configured to illuminate a tissue with at least one of a coherent light or a partially coherent light; a second arrangement configured to receive a further light reflected from the tissue and form a series of speckle patterns; and a third arrangement configured to obtain speckle pattern data at time intervals sufficient to measure a microscopic motion within the tissue structure or with a tissue adjacent to the structure; and a fourth arrangement configured to assess the tissue structure by analyzing spatial characteristics of the speckle pattern data to determine at least one of structural characteristics or biomechanical characteristics of the tissue structure, wherein the tissue structure is at least one of in vivo or an internal tissue structure. - View Dependent Claims (21, 22, 23)
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Specification