Probes, systems, and methods for examining tissue according to the dielectric properties thereof

• US 8,032,211 B2
• Filed: 05/01/2007
• Issued: 10/04/2011
• Est. Priority Date: 01/04/2002
• Status: Expired due to Term

• Current Assignee: Dune Medical Devices Ltd. (Dilon Technologies LLC)
• Original Assignee: Dune Medical Devices Ltd. (Dilon Technologies LLC)
• Inventors: Geltner, Iddo, Hashimshony, Dan, Cohen, Gil
• Primary Examiner(s): Hindenburg; Max
• Assistant Examiner(s): SZMAL, BRIAN SCOTT
• Application Number:
  US11/797,167
• Publication Number:
  US 20080021343A1
• Time in Patent Office: 1,617 Days
• Field of Search: 600/547, 600/306, 600/554, 606 32- 34, 606/41, 324642-646, 324/632
• US Class Current: 600/547
• CPC Class Codes: A61B 10/0041 Detection of breast cancer mammography by transillumination A61B5/0091, by X-rays A61B6/502, by ultrasonic means A61B8/0825
• CPC Class Codes: A61B 17/320016 Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes A61B10/0233, A61B17/29, A61B17/3207 take precedence
• CPC Class Codes: A61B 17/320783 through side-hole, e.g. sliding or rotating cutter inside catheter
• CPC Class Codes: A61B 2017/00026 Conductivity or impedance, e.g. of tissue
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes

Abstract

The present invention relates to probes, systems, and methods for tissue characterization by its dielectric properties, wherein a physical feature of the probe is designed to define and delimit a tissue volume, at a tissue edge, where characterization takes place. Thus, the probe for tissue-edge characterization comprises: a first inner conductor, which comprises: proximal and distal ends, with respect to a tissue edge, along an x-axis; a first sharp edge, inherently associated with the proximal end; at least one feature, issuing from the first inner conductor, substantially at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a generally predefined tissue volume, at the tissue edge, the tissue volume being generally defined by physical parameters associated with the at least one feature; and a dielectric material, which encloses the conductor, in the y-z planes.

Claims

1. A probe for tissue-edge characterization, comprising:

a first inner conductor, which comprises;

proximal and distal ends, with respect to a tissue edge, along an x-axis;

a first sharp edge, located at the proximal end;

at least one feature, issuing from the first inner conductor, at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a predefined tissue volume, at the tissue edge, the tissue volume being defined by physical parameters associated with the at least one feature; and

a dielectric material, which encloses the conductor, in the y-z planes;

wherein the probe is associated with a resecting tool.

2. A probe for tissue-edge characterization, comprising:

a first inner conductor, which comprises;

proximal and distal ends, with respect to a tissue edge, along an x-axis;

a first sharp edge, located at the proximal end;

at least one feature, issuing from the first inner conductor, at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a predefined tissue volume, at the tissue edge, the tissue volume being defined by physical parameters associated with the at least one feature; and

a dielectric material, which encloses the conductor, in the y-z planes;

wherein the probe is shaped for optimal fit of anatomical constraints.

3. A system for tissue-edge characterization, comprising:

a probe for tissue-edge characterization, which comprises;

a first inner conductor, which comprises;

proximal and distal ends, with respect to a tissue edge, along an x-axis;

a first sharp edge, located at the proximal end;

at least one feature, issuing from the first inner conductor, at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a predefined tissue volume, at the tissue edge, the tissue volume being defined by physical parameters associated with the at least one feature; and

a dielectric material, which encloses the conductor, in the y-z planes;

an external control and instrumentation system, for signal generation and signal analysis; and

a transmission line, for connecting between the probe and the external control and instrumentation system, wherein the probe further includes an array of probes, operative as a single testing device for tissue-edge characterization.

4. An array of probes, operative as a single testing device for tissue-edge characterization, wherein each probe of the array is constructed in accordance with claim 3.

5. The array of claim 4, shaped for optimal fit of anatomical constraints.

6. The array of claim 4, wherein each probe is associated with a transmission line.

7. The array of claim 6, wherein each probe is associated with a transmission line, connected to the distal end of the probe'"'"'s conductor, the transmission line being operative to transmit a signal to the probe'"'"'s conductor, for applying the electric signals to the tissue, and to transmit back a response signal, which corresponds to primary reflected electric signals.

8. The system of claim 3, wherein the transmission line is a coaxial cable.

9. The system of claim 3, wherein the array is shaped for optimal fit of anatomical constraints.

10. The system of claim 3, wherein the array is shaped for optimal characterization of tissue of a predetermined tissue specimen shape.

11. The system of claim 3, wherein each probe of the array of probes is associated with a transmission line.

12. The system of claim 3, wherein the array of probes is associated with a single transmission line.

13. The system of claim 3, wherein the probe is associated with a resecting tool.

14. The system of claim 3, wherein the probe is shaped for optimal characterization of tissue of predetermined tissue specimen shape.

15. The system of claim 3, wherein the probe is fitted within a catheter for intracorporeal insertion.

16. The system of claim 3, wherein the external control and instrumentation system comprises:

a signal generator, in communication with the probe, via the transmission line, for generating the electric signals;

a detector, in communication with the probe, via the transmission line, for detecting the reflected electric signals; and

a data processor for comparing electrical characteristics of the reflected electric signals with respect to the applied electric signals to produce an indication of the dielectric properties of tissue for examination.

17. The system of claim 16, wherein the electric signals are selected from the group consisting of:

a sinusoidal signal, a square pulse, a triangular pulse, a chirped pulse, a modulated pulse, a tailored pulse, and a combination thereof.

18. The system of claim 16, wherein the signal generator is configured for generating and applying electric signals of duration of the order of nanoseconds.

19. The system of claim 16, wherein the signal generator is configured for generating and applying electric signals of duration of the order of picoseconds.

20. The system of claim 16, wherein:

the signal generator is configured for generating and applying a series of the electric signals at a pulse repetition rate of a few Herz to a few giga-Herz.

21. The system of claim 16, wherein:

the detector is configured for detecting the primary reflected electric signals; and

the data processor is configured for comparing the primary reflected electric signals with the applied electric signals, to provide an indication of the impedance of the generally predefined tissue volume, at the tissue edge.

22. The system of claim 16, wherein:

the detector is configured for detecting the primary reflected electric signals; and

the data processor is configured for comparing the primary reflected electric signals with the applied electric signals, to provide an indication of the dielectric properties of the generally predefined tissue volume, at the tissue edge.

23. The system of claim 16, wherein the detector is a digitizing unit.

24. The system of claim 3, configured for sensing in real time.

25. The method of claim 24, wherein the array is shaped for optimal characterization of tissue of a predetermined tissue specimen shape.

26. A system for tissue-edge characterization, comprising:

a probe for tissue-edge characterization, which comprises;

a first inner conductor, which comprises;

proximal and distal ends, with respect to a tissue edge, along an x-axis;

a first sharp edge, located at the proximal end;

at least one feature, issuing from the first inner conductor, at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a predefined tissue volume, at the tissue edge, the tissue volume being defined by physical parameters associated with the at least one feature; and

a dielectric material, which encloses the conductor, in the y-z planes;

an external control and instrumentation system, for signal generation and signal analysis; and

a transmission line, for connecting between the probe and the external control and instrumentation system, wherein the probe is associated with a biopsy device.

27. A system for tissue-edge characterization, comprising:

a probe for tissue-edge characterization, which comprises;

a first inner conductor, which comprises;

proximal and distal ends, with respect to a tissue edge, along an x-axis;

a first sharp edge, located at the proximal end;

at least one feature, issuing from the first inner conductor, at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a predefined tissue volume, at the tissue edge, the tissue volume being defined by physical parameters associated with the at least one feature; and

a dielectric material, which encloses the conductor, in the y-z planes;

an external control and instrumentation system, for signal generation and signal analysis; and

a transmission line, for connecting between the probe and the external control and instrumentation system, wherein the probe is shaped for optimal fit of anatomical constraints.

28. A method for tissue-edge characterization, comprising:

providing a probe for tissue-edge characterization, comprising;

a first inner conductor, which comprises;

proximal and distal ends, with respect to a tissue edge, along an x-axis;

a first sharp edge, located at the proximal end;

at least one feature, issuing from the first inner conductor, at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a predefined tissue volume, at the tissue edge, the tissue volume being defined by physical parameters associated with the at least one feature; and

a dielectric material, which encloses the conductor, in the y-z planes;

bringing the probe to form contact with the tissue edge;

applying electric signals, associated with a wavelength λ

, to the tissue;

generating the enhanced localized electrical fringe fields in the tissue, within the generally predefined tissue volume, at the tissue edge;

producing primary reflected electric signals from the tissue, substantially only from the predefined tissue volume, at the tissue edge; and

sensing the primary reflected electric signals, from the predefined tissue volume, at the tissue edge, wherein the probe further includes an array of probes, operative as a single testing device for tissue-edge characterization.

29. The method of claim 28, wherein the array is shaped for optimal fit of anatomical constraints.

30. The method of claim 28, wherein the probe is associated with a resecting tool.

31. The method of claim 28, wherein the probe is shaped for optimal characterization of tissue of predetermined tissue specimen shape.

32. The method of claim 28, wherein the probe is fitted within a catheter for intracorporeal insertion.

33. A method for tissue-edge characterization, comprising:

providing a probe for tissue-edge characterization, comprising;

a first inner conductor, which comprises;

proximal and distal ends, with respect to a tissue edge, along an x-axis;

a first sharp edge, located at the proximal end;

at least one feature, issuing from the first inner conductor, at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a predefined tissue volume, at the tissue edge, the tissue volume being defined by physical parameters associated with the at least one feature; and

a dielectric material, which encloses the conductor, in the y-z planes;

bringing the probe to form contact with the tissue edge;

applying electric signals, associated with a wavelength λ

, to the tissue;

generating the enhanced localized electrical fringe fields in the tissue, within the generally predefined tissue volume, at the tissue edge;

producing primary reflected electric signals from the tissue, substantially only from the predefined tissue volume, at the tissue edge; and

sensing the primary reflected electric signals, from the predefined tissue volume, at the tissue edge, wherein the probe is associated with a biopsy device.

34. A method for tissue-edge characterization, comprising:

providing a probe for tissue-edge characterization, comprising;

a first inner conductor, which comprises;

proximal and distal ends, with respect to a tissue edge, along an x-axis;

a first sharp edge, located at the proximal end;

at least one feature, issuing from the first inner conductor, at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a predefined tissue volume, at the tissue edge, the tissue volume being defined by physical parameters associated with the at least one feature; and

a dielectric material, which encloses the conductor, in the y-z planes;

bringing the probe to form contact with the tissue edge;

applying electric signals, associated with a wavelength λ

, to the tissue;

generating the enhanced localized electrical fringe fields in the tissue, within the generally predefined tissue volume, at the tissue edge;

producing primary reflected electric signals from the tissue, substantially only from the predefined tissue volume, at the tissue edge; and

sensing the primary reflected electric signals, from the predefined tissue volume, at the tissue edge, wherein the probe is shaped for optimal fit of anatomical constraints.