Device and method for automatic threshold setting

• US 8,033,998 B2
• Filed: 12/28/2006
• Issued: 10/11/2011
• Est. Priority Date: 12/28/2006
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Kessels, Roger, Bullens, Roland W. M.
• Primary Examiner(s): Marmor, II; Charles A
• Assistant Examiner(s): Natnithithadha; Navin
• Application Number:
  US11/617,029
• Publication Number:
  US 20080161657A1
• Time in Patent Office: 1,748 Days
• Field of Search: 600/300, 600/301, 600/529, 600/543, 600/547, 600/481, 600/483, 600/484, 600/513
• US Class Current: 600/484
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00

Abstract

An implantable medical device for detecting physiological events includes a first sensor for sensing a first signal in a patient correlated to a first physiological condition, a second sensor for sensing a second signal in the patient corresponding to a second physiological condition and a third sensor for sensing a third signal in the patient corresponding to a third physiological condition responsive to the second physiological condition. Control circuitry for receiving the first, second and third signals is configured to determine a relationship between the second signal and the third signal, detect a change in the relationship between the second signal and the third signal and determine a threshold in response to detecting the change in the relationship between the second signal and the third signal. A physiological event is detected in response to the first signal crossing the determined threshold.

Claims

1. An implantable medical device, comprising:

a first sensor for sensing a first signal in a patient correlated to a first physiological condition;

a second sensor for sensing a second signal in the patient corresponding to a second physiological condition;

a third sensor for sensing a third signal in the patient corresponding to a third physiological condition responsive to the second physiological condition; and

control circuitry for receiving the first, second and third signals and being configured to determine a relationship between the second signal and the third signal, detect a change in the relationship between the second signal and the third signal, determine a threshold in response to detecting the change in the relationship between the second signal and the third signal, and detect an event in response to the first signal crossing the determined threshold;

wherein the first sensor signal is correlated to a thoracic fluid level, the second sensor signal is correlated to patient activity, and the third sensor signal is correlated to respiration rate, and

wherein detecting a change in the relationship between the second and third signals includes determining an activity level in response to sensing an increase in thoracic fluid level and sensing an increase in a respiration rate response to activity level compared to a previously measured respiration rate response, and

wherein determining the threshold includes determining a first sensor signal level corresponding to the increase in the respiration rate response.

2. An implantable medical device according to claim 1 further comprising alarm circuitry for generating an alarm in response to detection of the event.

3. An implantable medical device according to claim 1 wherein the first sensor signal is an impedance signal.

4. An implantable medical device according to claim 1 wherein determining the relationship between the second signal and the third signal includes measuring the third signal in response to the second signal corresponding to a first activity level and measuring the third signal in response to the second signal corresponding to a second activity level.

5. An implantable medical device according to claim 1 wherein detecting a change in the relationship between the second signal and the third signal includes sensing the second signal and the third signal in response to a change in the first signal.

6. An implantable medical device according to claim 5 wherein the change in the first signal corresponds to an increase in thoracic fluid level.

7. A method comprising employing an implantable medical device to perform the following steps:

sensing a first signal in a patient correlated to a first physiological condition;

sensing a second signal in the patient corresponding to a second physiological condition;

sensing a third signal in the patient corresponding to a third physiological condition responsive to the second physiological condition;

determining a relationship between the second signal and the third signal,

detecting a change in the relationship between the second signal and the third signal,

determining a threshold in response to the detected change in the relationship between the second signal and the third signal, and

detecting an event in response to the first signal crossing the determined threshold;

wherein the first signal is correlated to a thoracic fluid level, the second signal is correlated to patient activity, and the third signal is correlated to respiration rate, and

wherein detecting a change in the relationship between the second and third signals includes determining an activity level in response to sensing an increase in thoracic fluid level and sensing an increase in a respiration rate response to the activity level compared to a previously measured respiration rate response, and

wherein determining the threshold includes determining a first sensor signal level corresponding to the increase in the respiration rate response.

8. A method according to claim 7, further comprising generating an alarm in response to detection of the event.

9. A method according to claim 7, wherein the first signal is an impedance signal.

10. A method according to claim 7, wherein determining the relationship between the second signal and the third signal includes measuring the third signal in response to the second signal corresponding to a first activity level and measuring the third signal in response to the second signal corresponding to a second activity level.

11. A method according to claim 7, wherein detecting a change in the relationship between the second signal and the third signal includes sensing the second signal and the third signal in response to a change in the first signal.

12. A method according to claim 11, wherein the change in the first signal corresponds to an increase in thoracic fluid level.

13. A non-transitory computer-readable medium for storing a set of instructions which when implemented in an implantable medical device system including a microprocessor cause the system to:

sense a first signal in a patient correlated to a first physiological condition;

sense a second signal in the patient corresponding to a second physiological condition;

sense a third signal in the patient corresponding to a third physiological condition responsive to the second physiological condition;

determine a relationship between the second signal and the third signal,

detect a change in the relationship between the second signal and the third signal,

determine a threshold in response to the detected change in the relationship between the second signal and the third signal, and

detect an event in response to the first signal crossing the determined threshold;

wherein the first signal is correlated to a thoracic fluid level, the second signal is correlated to patient activity, and the third signal is correlated to respiration rate, and

wherein instructions for detecting a change in the relationship between the second and third signals include instructions for determining an activity level in response to sensing an increase in thoracic fluid level and sensing an increase in a respiration rate response to the activity level compared to a previously measured respiration rate response, and

wherein instructions for the threshold include instructions for determining a first sensor signal level corresponding to the increase in the respiration rate response.

14. A computer-readable medium according to claim 13, further comprising instructions which cause the system to generate an alarm in response to detection of the event.

15. A computer-readable medium according to claim 13, wherein the first signal is an impedance signal.

16. A computer-readable medium according to claim 13, wherein instructions for determining the relationship between the second signal and the third signal include instructions for measuring the third signal in response to the second signal corresponding to a first activity level and measuring the third signal in response to the second signal corresponding to a second activity level.

17. A computer-readable medium according to claim 13, wherein instructions for detecting a change in the relationship between the second signal and the third signal include instructions for sensing the second signal and the third signal in response to a change in the first signal.

18. A computer-readable medium according to claim 17, wherein the change in the first signal corresponds to an increase in thoracic fluid level.

19. An implantable medical device, comprising:

means for sensing a first signal in a patient correlated to a first physiological condition;

means for sensing a second signal in the patient corresponding to a second physiological condition;

means for sensing a third signal in the patient corresponding to a third physiological condition responsive to the second physiological condition;

means for determining a relationship between the second signal and the third signal,

means for detecting a change in the relationship between the second signal and the third signal,

means for determining a threshold in response to the detected change in the relationship between the second signal and the third signal, and

means for detecting an event in response to the first signal crossing the determined threshold;

wherein the first sensor signal is correlated to a thoracic fluid level, the second sensor signal is correlated to patient activity, and the third sensor signal is correlated to respiration rate, and

wherein detecting a change in the relationship between the second and third signals includes determining an activity level in response to sensing an increase in thoracic fluid level and sensing an increase in a respiration rate response to activity level compared to a previously measured respiration rate response, and

wherein determining the threshold includes determining a first sensor signal level corresponding to the increase in the respiration rate response.

20. An implantable medical device according to claim 19, further comprising alarm circuitry for generating an alarm in response to detection of the event.

21. An implantable medical device according to claim 19, wherein the first sensor signal is an impedance signal.

22. An implantable medical device according to claim 19, wherein determining the relationship between the second signal and the third signal includes measuring the third signal in response to the second signal corresponding to a first activity level and measuring the third signal in response to the second signal corresponding to a second activity level.

23. An implantable medical device according to claim 19, wherein detecting a change in the relationship between the second signal and the third signal includes sensing the second signal and the third signal in response to a change in the first signal.

24. An implantable medical device according to claim 23, wherein the change in the first signal corresponds to an increase in thoracic fluid level.