Ischemia detection using a heart sound sensor

• US 8,034,000 B2
• Filed: 07/28/2009
• Issued: 10/11/2011
• Est. Priority Date: 06/08/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhang, Yi, Siejko, Krzysztof Z., Fogoros, Richard, Brockway, Marina V., Dalal, Yousufali, Haro, Carlos
• Primary Examiner(s): Bertram; Eric D.
• Application Number:
  US12/510,962
• Publication Number:
  US 20090287106A1
• Time in Patent Office: 805 Days
• Field of Search: 600/528
• US Class Current: 600/528
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation

Abstract

A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient'"'"'s heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

Claims

1. A method comprising:

sensing a heart sound signal using a medical device, the heart sound associated with mechanical vibration of a heart of a patient;

establishing a baseline value of a characteristic of at least one of an S3 or S4 heart sound in the heart sound signal;

sensing at least one subsequent heart sound signal for the patient using the device;

deeming that an ischemic event occurred using at least a measured subsequent change in the heart sound characteristic from the established baseline value of the characteristic;

discriminating a transient ischemic event from an acute myocardial infarction (AMI) using the measured subsequent change in the heart sound characteristic from the established baseline value of the heart sound characteristic; and

providing an indication of the ischemic event or AMI to a user or process.

2. The method of claim 1, wherein deeming that an ischemic event occurred using at least a measured change includes deeming using a measured change in at least one heart sound signal characteristic from an established baseline value of the characteristic, the characteristic of the at least one of the S3 or S4 heart sound is selected from the group consisting of:

an amplitude of the heart sound of the heart sound signal;

a power spectrum of the heart sound;

an amplitude of the heart sound normalized with respect to an amplitude of a second heart sound;

an amplitude of the heart sound normalized with respect to a measured power of the heart sound signal measured during systole;

a frequency of occurrence of the heart sound in the heart sound signal; and

a duration of an occurrence of the heart sound in the heart sound signal.

3. The method of claim 1, wherein deeming that an ischemic event occurred is inferred at least in part by detecting a merging of S3 and S4 heart sounds in the heart sound signal.

4. The method of claim 1, wherein the baseline value of heart sound characteristic and subsequent change in the heart sound characteristic are sensed in association with a posture of a patient.

5. The method of claim 1, wherein the baseline heart sound characteristic and subsequent change in the heart sound characteristic are sensed in association with patient activity.

6. The method of claim 1, wherein the baseline heart sound characteristic and subsequent change in the heart sound characteristic are sensed in association with an electrical cardiac signal representative of cardiac activity of the patient.

7. The method of claim 1, wherein deeming that an ischemic event occurred includes ongoing monitoring for any measured changes from the established baseline of the heart sound characteristic.

8. The method of claim 1, further including activating an alarm indicative of the deemed ischemic event.

9. The method of claim 1, wherein deeming that an ischemic event occurred is inferred at least in part using both a measured change in a cardiac signal from an established baseline cardiac signal sensed using the device and the measured change in the heart sound characteristic.

10. The method of claim 9, wherein deeming an ischemic event occurred is inferred at least in part using a temporal relationship between the measured change in the heart sound characteristic from the established baseline heart sound characteristic and the measured change in a cardiac signal from the established baseline cardiac signal.

11. The method of claim 10, wherein deeming an ischemic event occurred includes using the temporal relationship of a sensed event indicated by the sensed cardiac signal and the measured change in the heart sound characteristic from the established baseline value of the heart sound characteristic.

12. The method of claim 1, wherein discriminating a transient ischemic event from an AMI event includes discriminating based on a duration of the measured subsequent change from the established baseline value of the heart sound characteristic.

13. The method of claim 1, wherein discriminating a transient ischemic event from an AMI event includes discriminating based on an amplitude of the measured subsequent change from the established baseline value of the heart sound characteristic.

14. The method of claim 1, wherein discriminating a transient ischemic event from an AMI event includes discriminating using a sensed event indicated by a sensed cardiac electrical signal and deeming the event an AMI event when the sensed cardiac event is no longer indicated by the sensed cardiac electrical signal while the measured change in the heart sound persists.

15. The method of claim 1, wherein discriminating a transient ischemic event from an AMI event includes discriminating using the measured change in the heart sound in association with at least one of a posture of a patient, patient activity, and a sensed cardiac electrical signal.

16. The method of claim 1, wherein sensing a heart sound signal using a medical device includes sensing a heart sound signal using an implantable medical device (IMD).

17. A method comprising:

sensing a heart sound signal using a medical device, the heart sound associated with mechanical vibration of a heart of a patient;

establishing a baseline value of a characteristic of at least one of an S3 or S4 heart sound in the heart sound signal;

sensing at least one subsequent heart sound signal for the patient using the device;

deeming that an ischemic event occurred at least in part using a measured change in the heart sound characteristic from the baseline value of the heart sound characteristic when a time constant of the change has a range of several seconds to several minutes;

determining a heart failure condition of a patient using the measured change in the heart sound signal from the baseline heart sound signal when the time constant has a range of several hours to several days;

providing an indication of the ischemic event or heart failure condition to a user or process.

18. The method of claim 17, further including activating an alarm indicative of the heart failure condition.

19. A method comprising:

sensing a heart sound signal using a medical device, the heart sound associated with mechanical vibration of a heart of a patient;

establishing a baseline value of a characteristic of at least one of an S3 or S4 heart sound in the heart sound signal;

sensing at least one subsequent heart sound signal for the patient using the device;

measuring the heart sound in association with a sensed electrical cardiac activity signal;

assigning a first weight to the measured subsequent change in the heart sound from the established baseline value of the heart sound characteristic and a second weight to a measured change in the electrical cardiac signal from an established baseline electrical cardiac signal; and

deeming an ischemic event occurred using at least a measured change in the value of the heart sound characteristic from the established baseline value of the characteristic, the measured change in the electrical cardiac signal, and the assigned weights; and

providing an indication of the ischemic event to a user or process.