Systems and methods for combining materials

• US 8,034,044 B2
• Filed: 04/04/2008
• Issued: 10/11/2011
• Est. Priority Date: 04/04/2008
• Status: Active Grant

• Current Assignee: B Braun Melsungen AG (B. Braun Holding GmbH & Co. KG)
• Original Assignee: B Braun Melsungen AG (B. Braun Holding GmbH & Co. KG)
• Inventors: Lee, Freddie Eng Hwee
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): PATEL, PRITESH ASHOK
• Application Number:
  US12/062,702
• Publication Number:
  US 20090254031A1
• Time in Patent Office: 1,285 Days
• Field of Search: 604/83
• US Class Current: 604/518
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2037 having valve means
• CPC Class Codes: A61J 1/2075 for external venting
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents

Abstract

A method of combining a drug in a first container and a liquid in a second container includes placing the first container and the second container in fluid communication with a housing, combining the liquid and the drug in the first container, transferring the liquid and the drug from the first container to the housing, and transferring the liquid and the drug from the housing to a third container.

Claims

1. In a closed system that includes a medical device, a first container containing a drug, a second container containing a liquid, a target container, and a pump, a combining and transferring method comprising:

placing the first container and the second container in fluid communication with the medical device;

combining the liquid and the drug in the first container to form a resultant mixture while effecting a system-level air exchange via an air vent assembly of the medical device such that equilibrium of pressure within at least the first container, the second container, and the medical device is substantially obtained; and

activating the pump to effect a transfer of at least some of the resultant mixture from the first container to the target container via a chamber of the medical device, wherein the transfer causes a moveable member within the chamber to move responsive to a level of the resultant mixture in the chamber to a position that restricts air flow into the target container.

2. The method of claim 1, further comprising restricting flow of the liquid from the medical device to the first container.

3. The method of claim 1, further comprising restricting flow of the liquid from the third container to the medical device.

4. The method of claim 1, wherein the pump is activated such that at least some of the resultant mixture is transferred from the medical device to the target container via the medical device at a pressure greater than one atmosphere.

5. The method of claim 1, further comprising activating at least two valves to effect the transfer of at least some of the resultant mixture from the first container to the target container via the medical device, wherein at least one of the two valves is operable to restrict air flow into the pump, thereby restricting the air flow into the target container.

6. The method of claim 1, wherein the medical device contains an air filter, and the method further comprises preventing the liquid from contacting the air filter.

7. The method of claim 1, wherein combining the liquid and the drug comprises elevating a position of the second container relative to a position of the first container.

8. The method of claim 1, further comprising:

activating a flow controller disposed between the first container and the second container to limit the flow of at least some of the liquid from the second container to the first container.

9. The method of claim 1, further comprising:

repeating the activating until all of the liquid from the second container is transferred to the target container via the first container and the medical device.

10. The method of claim 1, further comprising:

repeating the activating until a desired amount of the resultant mixture is transferred to the target container.