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Methods for treating pain by administering a nerve growth factor antagonist and an NSAID and compositions containing the same

  • US 8,034,346 B2
  • Filed: 12/22/2009
  • Issued: 10/11/2011
  • Est. Priority Date: 02/19/2003
  • Status: Expired due to Fees
First Claim
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1. A method for treating pain in an individual comprising administering to the individual an effective amount of an anti-nerve growth factor (NGF) antibody and an NSAID, whereby the anti-NGF antibody and the NSAID in conjunction provide effective pain relief, wherein the anti-NGF antibody comprises a heavy chain variable region comprising:

  • (i) a CDR1 having the sequence 5′

    GFSLIGYDLN 3′

    (SEQ ID NO;

    3),(ii) a CDR2 having the sequence 5′

    IIWGDGTTDYNSAVKS 3′

    (SEQ ID NO;

    4), and(iii) a CDR3 having the sequence 5′

    GGYWYATSYYFDY 3′

    (SEQ ID NO;

    5),andwherein the anti-NGF antibody comprises a light chain variable region comprising;

    (i) a CDR1 having the sequence 5′

    RASQSISNNLN 3′

    (SEQ ID NO;

    6),(ii) a CDR2 having the sequence 5′

    YTSRFHS 3′

    (SEQ ID NO;

    7), and(iii) a CDR3 having the sequence 5′

    QQEHTLPYT 3′

    (SEQ ID NO;

    8).

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