Antimicrobial compositions containing colloids of oligodynamic metals

• US 8,034,454 B2
• Filed: 08/10/2009
• Issued: 10/11/2011
• Est. Priority Date: 12/15/1999
• Status: Expired due to Fees

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Terry, Richard
• Primary Examiner(s): Nakarani; D. S.
• Application Number:
  US12/538,702
• Publication Number:
  US 20090293882A1
• Time in Patent Office: 792 Days
• Field of Search: 428/423.1, 427/2.3
• US Class Current: 428/423.1
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61L 2/238 Metals or alloys, e.g. oligodynamic metals
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2300/62 Encapsulated active agents, e.g. emulsified droplets
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: C08K 3/08 : Metals
• CPC Class Codes: C08L 2666/04 : Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
• CPC Class Codes: C08L 2666/54 : Inorganic substances
• CPC Class Codes: C08L 27/06 : Homopolymers or copolymers of vinyl chloride
• CPC Class Codes: C09D 175/08 : from polyethers
• CPC Class Codes: Y10T 428/31551 : Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31609 : Particulate metal or metal compound-containing
• CPC Class Codes: Y10T 428/31663 : As siloxane, silicone or silane

Abstract

The present invention relates to antimicrobial compositions, methods for the production of these compositions, and use of these compositions with medical devices, such as catheters, and implants. The compositions of the present invention advantageously provide varying release kinetics for the active ions in the compositions due to the different water solubilities of the ions, allowing antimicrobial release profiles to be tailored for a given application and providing for sustained antimicrobial activity over time. More particularly, the invention relates to polymer compositions containing colloids comprised of salts of one or more oligodynamic metals, such as silver. The process of the invention includes mixing a solution of one or more oligodynamic metal salts with a polymer solution or dispersion and precipitating a colloid of the salts by addition of other salts to the solution which react with some or all of the first metal salts. The compositions can be incorporated into articles or can be employed as a coating on articles such as medical devices. Coatings may be on all or part of a surface.

Claims

1. A catheter which has been dipped in a composition, the composition formed by combining:

(i) a polyurethane-urea block copolymer,

(ii) an oligodynamic metal colloid formed from one or more oligodynamic metal salts comprising at least one of NaCl and AgNO₃,

(iii) at least one organic solvent in which the polyurethane-urea block copolymer is soluble,

(iv) at least one alcohol, and

(v) water.

2. The catheter of claim 1 which is a latex Foley catheter.

3. The catheter according to claim 1, wherein the at least one organic solvent comprises at least one of acetone, tetrahydrofuran , dimethylformamide, dimethlysulfoxide and acetonitrile.

4. The catheter according to claim 3, wherein the at least one organic solvent comprises tetrahydrofuran.

5. The catheter according to claim 3, wherein the at least one alcohol comprises at least one of methanol, ethanol, propanol, isopropanol and butanol.

6. The catheter according to claim 1, wherein the at least one alcohol comprises at least one of methanol, ethanol, propanol, isopropanol and butanol.

7. The catheter according to claim 6, wherein the at least one alcohol comprises ethanol.

8. The catheter according to claim 1, wherein the at least one organic solvent comprises tetrahydrofuran and the at least one alcohol comprises ethanol.

9. A catheter of claim 1, wherein the oligodynamic metal colloid comprises AgCl.

10. A catheter of claim 9 which is a Foley catheter.

11. A catheter of claim 1, wherein the concentration of silver is approximately 15% by weight, based on coating solids in the composition.

12. A catheter of claim 11 which is a Foley catheter.

13. A catheter which has been dipped in a composition, the composition being formed by:

preparing a polyether polyurethane-urea block copolymer in a solution comprising tetrahydrofuran and ethanol;

adding a solution of 10% AgNO₃ in water to the polyurethane-urea block copolymer solution to produce a final silver concentration of approximately 15% by weight, based on coating solids in the solution; and

adding an aqueous solution of NaCl to the solution to produce a colloidal suspension of AgCl.

14. The catheter of claim 13 which is a latex Foley catheter.

15. A catheter which has been dipped in a composition the composition being formed by:

preparing a polyether polyurethane-urea block copolymer in a mixture of tetrahydrofuran and alcohol in a 75/25 ratio by weight;

adding a solution of 10% AgNO₃ in water to produce a final silver concentration of approximately 15% by weight, based on the weight of coating solids in the solution; and

adding an aqueous solution of NaCl to produce a colloid of AgCl.