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Apparatus and method for trapping bead based reagents within microfluidic analysis systems

  • US 8,034,628 B2
  • Filed: 07/07/2010
  • Issued: 10/11/2011
  • Est. Priority Date: 11/26/1999
  • Status: Active Grant
First Claim
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1. A microfluidic analysis system, comprising:

  • a) a substantially planar substrate having an upper surface;

    b) at least one main channel formed into said upper surface, said main channel having first and second ends and a defined direction of flow in use;

    c) a cover plate arranged over said planar substrate, said cover plate closing off said channel from above;

    d) a packing material having constituent particles that are non-polar, ande) a first weir formed across said main channel and between said first and second ends of said channel, said first weir providing at least one flow gap to allow, in use, at least some fluid to flow past said first weir while trapping said packing material the material comprising constituent particles that are generally larger than said flow gap.

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