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Methods of donor specific crossmatching

  • US 8,034,635 B2
  • Filed: 12/02/2008
  • Issued: 10/11/2011
  • Est. Priority Date: 05/16/2002
  • Status: Expired due to Fees
First Claim
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1. A method of cross-matching a donor and a recipient comprising:

  • (a) providing a donor sample containing, or suspected of containing, a precursor endothelial cell;

    (b) contacting the donor sample with a detection reagent to isolate the endothelial cell under conditions where the precursor endothelial cell and the detection reagent are capable of forming a complex;

    (c) separating said complex from the sample, thereby isolating said precursor endothelial cell from said biological sample;

    wherein the isolated precursor endothelial cell is CD34 negative and CD14 positive; and

    (d) screening a recipient sample for a reactivity with the isolated precursor endothelial cell wherein no reactivity of the recipient sample with the isolated precursor endothelial cell indicates compatibility between the donor and recipient.

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