Composition and methods for skin care

• US 8,034,788 B2
• Filed: 05/10/2006
• Issued: 10/11/2011
• Est. Priority Date: 05/10/2005
• Status: Expired due to Fees

• Current Assignee: Dermipsor Ltd.
• Original Assignee: Dermipsor Ltd.
• Inventors: Harel, Avikam, Bloch, Olga, Even-Chen, Zeev
• Primary Examiner(s): LEWIS, PATRICK T
• Application Number:
  US11/914,093
• Publication Number:
  US 20080312181A1
• Time in Patent Office: 1,980 Days
• Field of Search: None
• US Class Current: 514/23
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 31/593 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/606 Nucleosides; Nucleotides; Nucleic acids
• CPC Class Codes: A61K 8/67 Vitamins
• CPC Class Codes: A61K 8/675 Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde tocopheryl nicotinate A61K8/678
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Compositions useful in the treatment of skin atrophy and improvement of skin appearance and texture are disclosed. The methods include the topical administration of vitamin D3 or specific vitamin D3 analogs as an essential ingredient either on its own or in combination with cADPR and or nicotinamide. The compositions are particularly effective in preventing and treating signs of chronological and or photoaging including fine lines, wrinkles and discoloration.

Claims

1. A method for retarding, arresting, reversing or treating atrophy in skin of a mammalian subject in need thereof, the method comprising the step of:

topically applying to the skin of the subject a dermatologically effective amount of a composition comprising;

a first active agent of calcipotriol;

a second active agent of nicotinamide; and

a dermatologically acceptable carrier, thereby retarding, arresting, reversing or treating atrophy in the skin of the subject.

2. The method according to claim 1, wherein the subject is a human subject.

3. The method according to claim 1, wherein atrophy of the skin is associated with steroid-induced atrophy, menopausal induced atrophy or aging.

10. The method according to claim 1, wherein the composition consists essentially of calcipotriol, nicotinamide, and the dermatologically acceptable carrier, with the active agents present in amounts which, in combination, are sufficient to retard, arrest, or reverse atrophy in the skin of the subject.

11. The method according to claim 1, wherein the composition consists of calcipotriol, nicotinamide, and the dermatologically acceptable carrier, with the active agents present in amounts which, in combination, are sufficient to retard, arrest, or reverse atrophy in the skin of the subject.

12. The method according to claim 1, wherein the composition consists essentially of calcipotriol, nicotinamide, cyclic adenosine diphosphate ribose (cADPR) and the dermatologically acceptable carrier, with the active agents present in amounts which, in combination, are sufficient to prevent, retard, arrest, or reverse atrophy in the skin of the subject.

13. The method according to claim 1, wherein the composition consists of calcipotriol, nicotinamide, cyclic adenosine diphosphate ribose (cADPR) and the dermatologically acceptable carrier, with the active agents present in amounts which, in combination, are sufficient to retard, arrest, or reverse atrophy in the skin of the subject.

4. A method of treating an epidermal condition related to aging in a subject in need thereof, the method comprising the step of:

topically administering to the skin of the subject a dermatologically effective amount of a composition comprising;

a first active agent of calcipotriol;

a second active agent of nicotinamide; and

a dermatologically acceptable carrier, thereby treating an epidermal condition related to aging in the subject.

5. The method according to claim 4, wherein the subject is a human subject.

6. The method according to claim 4, wherein the epidermal condition related to aging is associated with chronological aging, photoaging or a combination of chronological aging and photoaging.

7. The method according to claim 4, wherein the epidermal condition is selected from at least one of the group consisting of fine lines, wrinkles, discoloration, sagging, enlarged pores, rough skin, dry skin, acne, alopecia and stretch marks.

8. The method according to claim 4, wherein the composition consists essentially of:

calcipotriol;

cyclic adenosine diphosphate ribose (cADPR);

nicotinamide; and

the dermatologically acceptable carrier, with the active agents present in amounts which, in combination, are sufficient to treat the epidermal condition related to aging in the subject.

14. The method according to claim 4, wherein the composition consists essentially of calcipotriol, nicotinamide and the dermatologically acceptable carrier.

15. The method according to claim 8, wherein the composition consists of calcipotriol, nicotinamide, cyclic adenosine diphosphate ribose (cADPR) and the dermatologically acceptable carrier.

9. A method of treating an epidermal condition related to aging in a subject in need thereof, the method comprising the step of:

topically administering to the skin of the subject a dermatologically effective amount of a composition consisting essentially of calcipotriol; and

a dermatologically acceptable carrier, thereby treating an epidermal condition related to aging in the subject.