RNAi modulation of MLL-AF4 and uses thereof
First Claim
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1. A method for treating a disorder associated with MLL-AF4 fusion expression comprising administering to a subject having or at risk for developing said disorder a composition comprising an iRNA agent, wherein said iRNA agent comprises a sense strand and an antisense strand and the antisense strand consists of SEQ ID NO:
- 15.
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Abstract
The invention relates to compositions and methods for modulating the expression of the MLL-AF4 fusion gene, and more particularly to the downregulation of MLL-AF4 by chemically modified oligonucleotides.
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Citations
30 Claims
- 1. A method for treating a disorder associated with MLL-AF4 fusion expression comprising administering to a subject having or at risk for developing said disorder a composition comprising an iRNA agent, wherein said iRNA agent comprises a sense strand and an antisense strand and the antisense strand consists of SEQ ID NO:
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27. A method for treating a proliferative disorder comprising administering to a subject a composition comprising an iRNA agent, wherein said iRNA agent comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to a part of mRNA encoding an MLL-AF4 fusion gene, wherein said region of complementarity is less than 30 nucleotides in length and the antisense strand comprises 15 or more contiguous nucleotides from SEQ ID NO:
- 15, and wherein said sense strand comprises 15 or more contiguous nucleotides of SEQ ID NO;
14. - View Dependent Claims (28)
- 15, and wherein said sense strand comprises 15 or more contiguous nucleotides of SEQ ID NO;
Specification