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Chemically modified small molecules

  • US 8,034,825 B2
  • Filed: 06/24/2010
  • Issued: 10/11/2011
  • Est. Priority Date: 12/16/2003
  • Status: Active Grant
First Claim
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1. A compound selected from the group consisting of:

  • 6-CH3-(OCH2CH2)5-O-naloxol;

    6-CH3-(OCH2CH2)6-O-naloxol;

    6-CH3-(OCH2CH2)8-O-naloxol; and

    6-CH3-(OCH2CH2)9-O-naloxol;

    or a pharmaceutically acceptable salt thereof, wherein the compound is an α

    -6 isomer, a β

    -6 isomer or a mixture of α

    -6 and β

    -6 isomers.

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