Methods for noninvasively measuring analyte levels in a subject
First Claim
Patent Images
1. A method of non-invasively estimating hemoglobin within biological tissue using optical coherence tomography (OCT) comprising:
- providing light having scattering properties sensitive to hemoglobin levels, the light comprising multiple wavelengths;
splitting the light into a sample beam and a reference beam;
irradiating biological tissue with the sample beamobtaining measurements of reflected light from the sample beam irradiating the biological tissue;
identifying portions of the measurements of the reflected light corresponding to measurements taken within a blood vessel within the biological tissue; and
estimating a hemoglobin level based on the measurements taken within the blood vessel.
6 Assignments
0 Petitions
Accused Products
Abstract
A method for noninvasively measuring analytes such as blood glucose levels includes using a non-imaging OCT-based system to scan a two-dimensional area of biological tissue and gather data continuously during the scanning. Structures within the tissue where measured-analyte-induced changes to the OCT data dominate over changes induced by other analytes are identified by focusing on highly localized regions of the data curve produced from the OCT scan which correspond to discontinuities in the OCT data curve. The data from these localized regions then can be related to measured analyte levels.
795 Citations
27 Claims
-
1. A method of non-invasively estimating hemoglobin within biological tissue using optical coherence tomography (OCT) comprising:
-
providing light having scattering properties sensitive to hemoglobin levels, the light comprising multiple wavelengths; splitting the light into a sample beam and a reference beam; irradiating biological tissue with the sample beam obtaining measurements of reflected light from the sample beam irradiating the biological tissue; identifying portions of the measurements of the reflected light corresponding to measurements taken within a blood vessel within the biological tissue; and estimating a hemoglobin level based on the measurements taken within the blood vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method of measuring hemoglobin concentration within biological tissue, the method comprising:
-
splitting light into a sample beam and a reference beam, the light comprising multiple wavelengths selected to accentuate contrast between hemoglobin cells and other biological constituents based on scattering differences; illuminating an area of biological tissue with the sample beam; collecting sample light reflected from within the illuminated biological tissue; generating optical coherence tomography (OCT) measurements based at least partly on comparing the reference beam with the reflected sample light; and processing the OCT measurements to determine a hemoglobin level of the biological tissue based at least partly on identifying the hemoglobin cells. - View Dependent Claims (11, 12, 13, 14, 15, 16)
-
-
17. A method for non-invasively determining a hemoglobin level using an optical coherence tomography (OCT) sensor comprising:
-
generating OCT measurements using an OCT sensor on biological tissue; determining a first OCT scattering profile and a second OCT scattering profile from the OCT measurements; comparing the first OCT scattering profile with the second OCT scattering profile; identifying a localized region corresponding to a particular tissue location of the biological tissue based at least partly upon the comparison of the first and the second OCT scattering profile, the localized region identifying portions of the OCT measurements where measurement changes due to blood hemoglobin predominate; and determining a blood hemoglobin level in the biological tissue based at least partly on analyzing OCT measurements corresponding to the localized region. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
-
-
27. A physiological monitoring system for determining a blood analyte level using an optical coherence tomography (OCT) sensor, the system comprising:
-
a non-invasive OCT sensor configured to scan an area of biological tissue and interferometrically scan in a depth dimension during a period of time; and a physiological monitor comprising at least one processor, the physiological monitor configured to; identify a localized region corresponding to a tissue location based at least partly upon a differential comparison of a first and a second OCT scattering profile; and determine a blood hemoglobin level in the biological tissue based at least partly on analyzing OCT measurements corresponding to the localized region.
-
Specification