Implantable device with remodelable material and covering material
First Claim
1. An implantable radially expandable medical device moveable from a radially compressed state to a radially expanded state, and having an interior surface defining an interior lumen and an exterior surface, the medical device comprising:
- a substantially non-remodelable covering material configured as a first tubular sleeve having a first abluminal side defining at least a first portion of the exterior surface of the medical device and a first luminal side defining a first portion of the interior surface of the medical device;
a remodelable material configured as a second tubular sleeve and positioned concentrically within the covering material, the remodelable material having a second abluminal side and a second luminal side defining a second portion of the interior surface of the medical device; and
a radially expandable support frame attached to the abluminal side of the covering material and defining at least a second portion of the exterior surface of the medical device, the radially expandable support frame defines a proximal portion comprising a proximal flared end of the support frame, a distal portion comprising a distal flared end of the support frame, and an intermediate portion extending along the entire axial length between the proximal and distal flared ends and comprising a connecting member extending between and connecting the proximal and distal flared ends, each of the proximal and distal flared ends having an outer diameter that is greater than the outer diameter of the intermediate portion when the medical device is in the radially expanded state;
wherein the covering material comprises a second proximal flared end and a second distal flared end and extends longitudinally from a point in the proximal flared end of the support frame, through the intermediate portion and to a point in the distal flared end of the support frame such that the second proximal flared end is disposed radially within the proximal flared end of the support frame and the second distal flared end is disposed radially within the distal flared end of the support frame;
wherein the remodelable material extends along the entire length of the intermediate portion of the support frame and does not extend into the proximal or distal portions of the support frame;
wherein the first and second portions of the interior surface of the medical device are exposed to fluid flow when the medical device is placed within a body vessel and expanded to the radially expanded state.
3 Assignments
0 Petitions
Accused Products
Abstract
Medical devices for implantation within a body vessel can include a remodelable material, such as an extracellular matrix material, positioned within a lumen defined by an outer covering material. The covering material is preferably substantially non-remodelable, and can be supported by a radially expandable frame. The medical device can also include a valve means positioned within the covering material. The valve means can include one or more valve leaflets formed from the remodelable material, and a separate valve support frame. One or more therapeutic agents can be associated with the remodelable material or the covering material.
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Citations
15 Claims
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1. An implantable radially expandable medical device moveable from a radially compressed state to a radially expanded state, and having an interior surface defining an interior lumen and an exterior surface, the medical device comprising:
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a substantially non-remodelable covering material configured as a first tubular sleeve having a first abluminal side defining at least a first portion of the exterior surface of the medical device and a first luminal side defining a first portion of the interior surface of the medical device; a remodelable material configured as a second tubular sleeve and positioned concentrically within the covering material, the remodelable material having a second abluminal side and a second luminal side defining a second portion of the interior surface of the medical device; and a radially expandable support frame attached to the abluminal side of the covering material and defining at least a second portion of the exterior surface of the medical device, the radially expandable support frame defines a proximal portion comprising a proximal flared end of the support frame, a distal portion comprising a distal flared end of the support frame, and an intermediate portion extending along the entire axial length between the proximal and distal flared ends and comprising a connecting member extending between and connecting the proximal and distal flared ends, each of the proximal and distal flared ends having an outer diameter that is greater than the outer diameter of the intermediate portion when the medical device is in the radially expanded state; wherein the covering material comprises a second proximal flared end and a second distal flared end and extends longitudinally from a point in the proximal flared end of the support frame, through the intermediate portion and to a point in the distal flared end of the support frame such that the second proximal flared end is disposed radially within the proximal flared end of the support frame and the second distal flared end is disposed radially within the distal flared end of the support frame; wherein the remodelable material extends along the entire length of the intermediate portion of the support frame and does not extend into the proximal or distal portions of the support frame; wherein the first and second portions of the interior surface of the medical device are exposed to fluid flow when the medical device is placed within a body vessel and expanded to the radially expanded state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An implantable radially expandable medical device moveable from a radially compressed state to a radially expanded state, and having an interior surface defining an interior lumen and an exterior surface, the medical device comprising:
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a substantially non-remodelable covering material configured as a first tubular sleeve having a first abluminal side defining at least a first portion of the exterior surface of the medical device and a first luminal side defining a first portion of the interior surface of the medical device; a remodelable material configured as a second tubular sleeve and positioned concentrically within the covering material, the remodelable material having a second abluminal side and a second luminal side defining a second portion of the interior surface of the medical device; a radially expandable support frame attached to the abluminal side of the covering material and defining at least a second portion of the exterior surface of the medical device, the support frame defining a proximal portion comprising a proximal flared end of the support frame, a distal portion comprising a distal flared end of the support frame, and an intermediate portion extending along the entire axial length between the proximal and distal flared ends and comprising a connecting member extending between and connecting the proximal and distal flared ends; and a valve means positioned at least partially within the interior lumen of the medical device, the valve means comprising a valve leaflet comprising the remodelable material; wherein the covering material comprises a second proximal flared end and a second distal flared end and extends longitudinally from a point in the proximal flared end through the intermediate portion and to a point in the distal flared end such that the second proximal flared end is disposed radially within the proximal flared end of the support frame and the second distal flared end is disposed radially within the distal flared end of the support frame; and wherein the remodelable material is disposed in the intermediate portion and does not extend into the proximal or distal portions; and wherein the first and second portions of the interior surface of the medical device are exposed to fluid flow when the medical device is placed within a body vessel and expanded to the radially expanded state.
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15. An implantable radially expandable medical device moveable from a radially compressed state to a radially expanded state, and having an interior surface defining an interior lumen and an exterior surface, the medical device comprising:
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a substantially non-remodelable covering material configured as a first tubular sleeve having a first abluminal side defining at least a first portion of the exterior surface of the medical device and a first luminal side defining a first portion of the interior surface of the medical device, the covering material defining a flared proximal end and a flared distal end; a remodelable material configured as a second tubular sleeve and positioned concentrically within the covering material, the remodelable material having a second abluminal side and a second luminal side defining a second portion of the interior surface of the medical device; a radially expandable support frame attached to the abluminal side of the covering material and defining at least a second portion of the exterior surface of the medical device, the support frame defining a proximal portion comprising a proximal flared end of the support frame, a distal portion comprising a distal flared end of the support frame, and an intermediate portion extending along the entire axial length between the proximal and distal flared ends and comprising a connecting member extending between and connecting the proximal and distal flared ends; and a valve means positioned at least partially within the interior lumen of the medical device, the valve means comprising a valve leaflet comprising the remodelable material; wherein the covering material comprises a second proximal flared end and a second distal flared end and extends longitudinally from a point in the proximal flared end through the intermediate portion and to a point in the distal flared end such that the second proximal flared end is disposed radially within the proximal flared end of the support frame and the second distal flared end is disposed radially within the distal flared end of the support frame; wherein the remodelable material is disposed in the intermediate portion and does not extend into the proximal or distal portions; wherein the flared proximal end is disposed within the proximal portion and the flared distal end is disposed within the distal portion; and wherein the first and second portions of the interior surface of the medical device are exposed to fluid flow when the medical device is placed within a body vessel and expanded to the radially expanded state.
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Specification