Process for the preparation of coated polymer particles

• US 8,038,987 B2
• Filed: 11/27/2006
• Issued: 10/18/2011
• Est. Priority Date: 07/17/2003
• Status: Active Grant

• Current Assignee: Invitrogen Dynal AS (Invitrogen Dynal Holding AS)
• Original Assignee: Invitrogen Dynal AS (Invitrogen Dynal Holding AS)
• Inventors: Hofsløkken, Nini Kjus, Kilaas, Lars, Schmid, Ruth, Nilsen, Tom-Nils, Berge, Arvid Trygve, Stenstad, Per, Bjorgum, Jon Olav, Fonnum, Geir, Aksnes, Elin Marie
• Primary Examiner(s): Hartley; Michael G
• Assistant Examiner(s): SCHLIENTZ, LEAH H
• Application Number:
  US11/563,598
• Publication Number:
  US 20070098639A1
• Time in Patent Office: 1,786 Days
• Field of Search: 424/489, 424/490, 424/497, 424/501, 424/9.3, 424/9.32, 424/9.322, 435/180, 427/212, 427/222, 427/372.2, 427/385.5, 428/357, 428/403, 428/407, 428/413, 525/185, 525/187
• US Class Current: 424/9.322
• CPC Class Codes: B82Y 25/00 Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
• CPC Class Codes: C08F 8/30 Introducing nitrogen atoms or nitrogen-containing groups
• CPC Class Codes: G01N 33/5434 using magnetic particle immunoreagent carriers which constitute new materials per se
• CPC Class Codes: H01F 1/0045 Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use preparation of fullerenes in general C01B32/15
• CPC Class Codes: Y10T 428/29 Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
• CPC Class Codes: Y10T 428/2991 Coated
• CPC Class Codes: Y10T 428/2998 including synthetic resin or polymer
• CPC Class Codes: Y10T 428/31511 Of epoxy ether
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]

Abstract

A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting porous, surface-functionalized, superparamagnetic crystal-containing polymer particles of diameter 0.5 to 1.8 μm with at least one polyisocyanate and at least one diol or at least one epoxide.

Claims

1. A process for the preparation of coated polymer particles containing superparamagnetic crystals, the process comprising reacting porous, surface-functionalized, superparamagnetic crystal-containing polymer particles of diameter 0.5 to 1.8 μ

m with at least two epoxide compounds, at least one of which having an unsaturated carbon-carbon bond copolymerizable with an acrylic monomer; and

reacting the formed particles with an acrylic monomer.

2. The process of claim 1, wherein the acrylic monomer is acrylic acid.

3. The process of claim 1, wherein the acrylic monomer is acrylamide.

4. The process of claim 1, wherein the acrylic monomer is reacted with N-hydroxysuccinimide or with streptavidin.

5. The process of claim 1, wherein at least one of the at least two epoxide compounds is a bisepoxide compound.

6. The process of claim 1, wherein the at least two epoxide compounds are selected from the group consisting of glycidol and 1,4-bis-(2,3-epoxypropoxy)butane.

7. The process of claim 1, wherein the at least two epoxide compounds are selected from the group consisting of 1,4-bis-(2,3-epoxypropoxy)butane and 2,2-bis(4-(2,3-epoxypropoxy)phenyl)-propane.

8. The process of claim 1, wherein the at least two epoxide compounds are selected from the group consisting of glycidol, allylglycidyl ether and 1,4-bis-(2,3-epoxypropoxy)butane.

9. The process of claim 1, wherein one of the at least two epoxide compounds has a molecular weight of 150 g/mol to 1000 g/mol.