Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
First Claim
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1. A cell-free tissue-engineering scaffold, comprising:
- a) a microporous scaffold comprising a poly(lactide-co-glycolide) co-polymer; and
b) a nanofibrous, nanoporous hydrogel coating on a surface of said scaffold, wherein said coating is formed from self-assembling peptides selected from the group consisting of NH2-RADARADARADARADA-COOH (SEQ ID NO;
1) and NH2-KLDLKLDLKLDL-COOH (SEQ ID NO;
2), and wherein at least a portion of said hydrogel is disposed within pores of said microporous scaffold.
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Abstract
The present invention is directed to tissue-engineering scaffolds containing both a microporous scaffold made from a biocompatible material suitable for use in tissue-engineering scaffolds and a nanofiberous, nanoporous hydrogel formed from a self-assembling peptide, where at least a portion of the hydrogel is disposed within the pores of the microporous scaffold, thus providing tissue-engineering scaffolds having average pore diameters in the nanometer range and that provide both mechanical properties suitable for implantation into a body of a mammal and excellent tissue response once implanted in the body.
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Citations
14 Claims
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1. A cell-free tissue-engineering scaffold, comprising:
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a) a microporous scaffold comprising a poly(lactide-co-glycolide) co-polymer; and b) a nanofibrous, nanoporous hydrogel coating on a surface of said scaffold, wherein said coating is formed from self-assembling peptides selected from the group consisting of NH2-RADARADARADARADA-COOH (SEQ ID NO;
1) and NH2-KLDLKLDLKLDL-COOH (SEQ ID NO;
2), and wherein at least a portion of said hydrogel is disposed within pores of said microporous scaffold. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A cell-free tissue-engineering scaffold, comprising:
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a) a unitary microporous scaffold formed of a nonbiodegradable polymer suitable for use in tissue-engineering scaffolds; and b) a nanofibrous, nanoporous hydrogel coating on a surface of said scaffold wherein said coating is formed from self-assembling peptides selected from the group consisting of NH2-RADARADARADARADA-COOH (SEQ ID NO;
1) and NH2-KLDLKLDLKLDL-COOH (SEQ ID NO;
2), and wherein at least a portion of said hydrogel is disposed within pores of said microporous scaffold. - View Dependent Claims (14)
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Specification