High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
First Claim
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1. A method of treating, preventing, or ameliorating a medical condition of a mammal, comprising:
- treating a topical site of a mammal using a device,immediately removing the device from the topical site after the device has perforated the skin, andapplying an effective amount of an agent to the topical site to allow the agent to penetrate into the body of the mammal,wherein the device comprises an array of microstructures, andwherein the microstructure has an aspect ratio of about 10;
1 or higher.
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Abstract
A method of usign a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.
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Citations
14 Claims
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1. A method of treating, preventing, or ameliorating a medical condition of a mammal, comprising:
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treating a topical site of a mammal using a device, immediately removing the device from the topical site after the device has perforated the skin, and applying an effective amount of an agent to the topical site to allow the agent to penetrate into the body of the mammal, wherein the device comprises an array of microstructures, and wherein the microstructure has an aspect ratio of about 10;
1 or higher. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of treating, preventing, or ameliorating a medical condition of a mammal, comprising:
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treating a topical site of a mammal using a device, immediately removing the device from the topical site after the device has perforated the skin, and applying an effective amount of an agent to the topical site to allow the agent to penetrate into the body of the mammal, wherein the device comprises an array of microstructures having an aspect ratio of about 10;
1 or higher,wherein the microstructure is a microneedle, microblade, microknife, or a combination thereof, wherein the microneedle comprises a tip in nanoscale dimension and a body in microscale dimension, and wherein the microblade or microknife comprises an edge in nanoscale dimension and a body in microscale dimension. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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Specification