Flow-inflated diffusion therapeutic delivery
First Claim
1. A device for delivering therapeutic agent to a target site in a vessel having a vessel wall and a vessel interior, the device comprising:
- a first infusion lumen having a proximal end, a distal end, and a longitudinal axis, the first infusion lumen containing a therapeutic agent;
a second infusion lumen having a proximal end, a distal end, and a longitudinal axis, the second infusion lumen containing a substance for mixing with the therapeutic agent; and
an inflatable balloon disposed at the distal ends of the first and second infusion lumens and in fluid communication with the first and second infusion lumens, the balloon having a proximal end, a distal end and an intermediate surface between the proximal end and distal end, the intermediate surface configured to contact the vessel wall, the inflatable balloon being the only balloon in fluid communication with the first and second infusion lumens, the inflatable balloon having an exit outlet in only the distal end of the balloon;
wherein the device is configured to exert pressure, such that when the exerted pressure is greater than a target pressure the therapeutic agent exits the inflatable balloon through the exit outlet into the vessel interior.
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Accused Products
Abstract
The present application includes devices, systems and methods for therapeutic agent delivery. A device in accord with the invention may include a first infusion lumen having a proximal end, a distal end, a longitudinal axis and a therapeutic agent. This device may also include an inflatable balloon in fluid communication with the first infusion lumen, the inflatable balloon having an exit outlet wherein the device is configured to exert pressure at a target site with an external surface of the balloon, the exerted pressure greater than a target pressure prior to the therapeutic agent exiting the inflatable balloon. A method in accord with the invention may include positioning a delivery device near an intended treatment site, injecting therapeutic agent through an infusion lumen into an inflatable balloon, and determining a target pressure at a target site by monitoring the blood pressure of a patient.
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Citations
22 Claims
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1. A device for delivering therapeutic agent to a target site in a vessel having a vessel wall and a vessel interior, the device comprising:
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a first infusion lumen having a proximal end, a distal end, and a longitudinal axis, the first infusion lumen containing a therapeutic agent; a second infusion lumen having a proximal end, a distal end, and a longitudinal axis, the second infusion lumen containing a substance for mixing with the therapeutic agent; and an inflatable balloon disposed at the distal ends of the first and second infusion lumens and in fluid communication with the first and second infusion lumens, the balloon having a proximal end, a distal end and an intermediate surface between the proximal end and distal end, the intermediate surface configured to contact the vessel wall, the inflatable balloon being the only balloon in fluid communication with the first and second infusion lumens, the inflatable balloon having an exit outlet in only the distal end of the balloon; wherein the device is configured to exert pressure, such that when the exerted pressure is greater than a target pressure the therapeutic agent exits the inflatable balloon through the exit outlet into the vessel interior. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A device to deliver a therapeutic agent, comprising:
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a guide wire having a proximal end, a distal end, and a longitudinal axis; a first infusion lumen having a proximal end, a distal end, and a longitudinal axis; a second infusion lumen having a proximal end, a distal end, and a longitudinal axis; and an inflatable balloon is disposed at the distal ends of the infusion lumens, the inflatable balloon being the only balloon in fluid communication with the first and second infusion lumens, wherein the balloon has a proximal end, a distal end and an intermediate surface between the proximal end and distal end, and wherein the longitudinal axis of the inflatable balloon is parallel to the longitudinal axes of the infusion lumens; wherein the guide wire is disposed parallel to the longitudinal axes of the infusion lumens; and wherein the balloon contains an exit outlet in only the distal end of the balloon, the exit outlet configured to restrict flow of therapeutic agent from the balloon and also configured to retard the release of therapeutic agent from the balloon until therapeutic agent pressure within the balloon reaches a target pressure. - View Dependent Claims (20, 21)
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22. A method of delivering a therapeutic agent within a vessel having a vessel wall and a vessel interior, the method comprising the steps of:
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positioning a delivery device having a first infusion lumen, a second infusion lumen, an inflatable balloon, a proximal end, a distal end, and a longitudinal axis near an intended treatment site in the vessel, the inflatable balloon being the only balloon in fluid communication with the first and second infusion lumens, the balloon having a proximal end, a distal end and an intermediate surface between the proximal end and distal end, the intermediate surface configured to contact the vessel wall, the balloon having an exit outlet in only the distal end of the balloon; injecting the therapeutic agent through the first infusion lumen into the inflatable balloon, wherein the therapeutic agent causes the inflatable balloon to inflate to a target pressure; injecting a substance through the second infusion lumen for mixing with the therapeutic agent; determining a target pressure at a target site by monitoring the blood pressure of a patient; and delivering the therapeutic agent through the exit outlet into the interior of the vessel when a pressure inside the balloon exceeds the target pressure.
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Specification