Methods and compositions for treating amyloid-related diseases

• US 8,044,100 B2
• Filed: 12/21/2005
• Issued: 10/25/2011
• Est. Priority Date: 12/22/2004
• Status: Expired due to Fees

• Current Assignee: BHI Limited Partnership
• Original Assignee: BELLUS Health, Inc.
• Inventors: Delorme, Daniel, Samim, Bita, Bouzide, Abderrahim, Bachand, Benoit, Gervais, Francine, Atfani, Mohamed, Valade, Isabelle, Levesque, Sophie, Wu, Xinfu, Migneault, David, Kong, Xianqi
• Primary Examiner(s): POWERS, FIONA
• Application Number:
  US11/316,693
• Publication Number:
  US 20060223855A1
• Time in Patent Office: 2,134 Days
• Field of Search: None
• US Class Current: 514/578
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: C07C 2601/02 with a three-membered ring
• CPC Class Codes: C07C 2601/04 with a four-membered ring
• CPC Class Codes: C07C 2601/08 the ring being saturated
• CPC Class Codes: C07C 2601/14 The ring being saturated
• CPC Class Codes: C07C 2601/18 with a ring being at least seven-membered
• CPC Class Codes: C07C 2602/08 the other ring being five-membered, e.g. indane
• CPC Class Codes: C07C 2602/10 the other ring being six-membered, e.g. tetraline
• CPC Class Codes: C07C 2602/42 : the bicyclo ring system containing seven carbon atoms
• CPC Class Codes: C07C 2603/74 : Adamantanes
• CPC Class Codes: C07C 309/14 : containing amino groups bound to the carbon skeleton
• CPC Class Codes: C07C 309/19 : of a saturated carbon skeleton containing rings
• CPC Class Codes: C07C 309/21 : containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
• CPC Class Codes: C07C 309/24 : of a carbon skeleton containing six-membered aromatic rings
• CPC Class Codes: C07C 309/26 : containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
• CPC Class Codes: C07D 207/12 : Oxygen or sulfur atoms
• CPC Class Codes: C07D 207/333 : Radicals substituted by oxygen or sulfur atoms
• CPC Class Codes: C07D 209/08 : with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
• CPC Class Codes: C07D 209/16 : Tryptamines
• CPC Class Codes: C07D 209/36 : in position 3, e.g. adrenochrome
• CPC Class Codes: C07D 209/44 : Iso-indoles; Hydrogenated iso-indoles
• CPC Class Codes: C07D 209/48 : with oxygen atoms in positions 1 and 3, e.g. phthalimide
• CPC Class Codes: C07D 209/86 : with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
• CPC Class Codes: C07D 211/06 : having no double bonds between ring members or between ring members and non-ring members
• CPC Class Codes: C07D 211/14 : with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
• CPC Class Codes: C07D 211/18 : with substituted hydrocarbon radicals attached to ring carbon atoms
• CPC Class Codes: C07D 211/34 : with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 211/48 : having an acyclic carbon atom attached in position 4
• CPC Class Codes: C07D 211/52 : having an aryl radical as the second substituent in position 4
• CPC Class Codes: C07D 211/58 : attached in position 4
• CPC Class Codes: C07D 211/64 : having an aryl radical as the second substituent in position 4
• CPC Class Codes: C07D 211/70 : with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 211/82 : with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 213/04 : having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 213/20 : Quaternary compounds thereof
• CPC Class Codes: C07D 213/50 : Ketonic radicals
• CPC Class Codes: C07D 213/75 : Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
• CPC Class Codes: C07D 213/82 : in position 3
• CPC Class Codes: C07D 217/04 : with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
• CPC Class Codes: C07D 219/10 : attached in position 9
• CPC Class Codes: C07D 231/44 : Oxygen and nitrogen or sulfur and nitrogen atoms
• CPC Class Codes: C07D 233/54 : having two double bonds between ring members or between ring members and non-ring members
• CPC Class Codes: C07D 235/28 : Sulfur atoms
• CPC Class Codes: C07D 257/04 : Five-membered rings
• CPC Class Codes: C07D 275/06 : with hetero atoms directly attached to the ring sulfur atom
• CPC Class Codes: C07D 277/66 : with aromatic rings or ring systems directly attached in position 2
• CPC Class Codes: C07D 295/073 : with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• CPC Class Codes: C07D 295/088 : to an acyclic saturated chain
• CPC Class Codes: C07D 307/14 : Radicals substituted by nitrogen atoms not forming part of a nitro radical
• CPC Class Codes: C07D 307/52 : Radicals substituted by nitrogen atoms not forming part of a nitro radical
• CPC Class Codes: C07D 317/58 : Radicals substituted by nitrogen atoms nitro radicals C07D317/52
• CPC Class Codes: C07D 327/04 : Five-membered rings
• CPC Class Codes: C07D 327/06 : Six-membered rings
• CPC Class Codes: C07D 327/08 : [b,e]-condensed with two six-membered carbocyclic rings
• CPC Class Codes: C07D 333/20 : by nitrogen atoms nitro, nitroso radicals C07D333/12
• CPC Class Codes: C07D 333/34 : Sulfur atoms
• CPC Class Codes: C07D 409/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 471/04 : Ortho-condensed systems
• CPC Class Codes: C07D 471/08 : Bridged systems
• CPC Class Codes: C07K 5/06 : Dipeptides

Abstract

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

Claims

1. A compound of the formula (XII):

3. A pharmaceutical composition comprising a compound according to claim 1.

5. The compound of claim 1, wherein R^h is hydrogen.

6. The compound of claim 5, wherein R^j, R^m, and R^o are each hydrogen.

7. The compound of claim 5, wherein R^j, R^k, R^m, Rⁿ and R^o are each hydrogen.

8. The compound of claim 7, wherein Rⁱ is ethyl, propyl, butyl, pentyl, hexyl or heptyl.

9. The compound of claim 1, wherein said compound has the structure:

10. The compound of claim 9, wherein said compound has the structure:

11. The compound of claim 9, wherein said compound has the structure:

2. A compound selected from the group consisting of:

4. A pharmaceutical composition comprising a compound selected from the group consisting of: