Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy

• US 8,045,177 B2
• Filed: 04/17/2008
• Issued: 10/25/2011
• Est. Priority Date: 04/17/2007
• Status: Active Grant

• Current Assignee: Massachusetts Eye And Ear Infirmary (Foundation of The Massachusetts Eye and EAR Infirmary Incorporated), The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: Massachusetts Eye And Ear Infirmary (Foundation of The Massachusetts Eye and EAR Infirmary Incorporated), The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Rosowski, John, Merchant, Saumil, Yelin, Dvir, Bouma, Brett Eugene, Tearney, Guillermo J.
• Primary Examiner(s): Chowdhury; Tarifur
• Assistant Examiner(s): HANSEN, JONATHAN M
• Application Number:
  US12/104,689
• Publication Number:
  US 20080262314A1
• Time in Patent Office: 1,286 Days
• Field of Search: 356/502, 356/456, 356484-486, 600/160
• US Class Current: 356/502
• CPC Class Codes: A61B 1/227 for ears, i.e. otoscopes
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/4504 Bones A61B5/4547 takes precedence

Abstract

An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electro-magnetic radiation within a first wavelength range may be provided on the portion of the sample so as to determine at least one first transverse location of the portion. At least two second different wavelengths of at least one second electro-magnetic radiation may also be provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. It is possible to obtain a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, whereas the motion is effectuated by at least one of a sound wave. Further, the imaging information of the portion can be provided based on the first transverse location, the second transverse location and the motion.

Claims

1. An apparatus for providing imaging information associated with at least one portion of a sample, comprising:

at least one first arrangement configured to provide (i) at least two first different wavelengths of at least one first electro-magnetic radiation within a first wavelength range provided on the at least one portion of the sample so as to determine at least one first transverse location of the portion, and (ii) at least two second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion;

at least one second arrangement configured to obtain a relative phase between at least one third electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, wherein the motion is effectuated by at least one of a sound wave; and

at least one third arrangement configured to provide the imaging information of the portion based on the at least one first transverse location, the at least one second transverse location and the motion.

2. The apparatus according to claim 1, wherein the sound wave includes an ultra-sound wave.

3. The apparatus according to claim 1, wherein the sample is an anatomical structure.

4. The apparatus according to claim 1, wherein the sample is at least one portion of a bone.

5. The apparatus according to claim 1, wherein the sample is at least one portion of an ear.

6. The apparatus according to claim 1, wherein the sound wave has a frequency of approximately 0.1 Hz to 10 kHz.

7. The apparatus according to claim 1, wherein the sound wave has a frequency of approximately 100 Hz to 20 kHz.

8. The apparatus according to claim 1, wherein the sound wave impacts the tympanic membrane of the sample.

9. The apparatus according to claim 1, wherein the first and second arrangements are provided in a probe which is configured to be inserted into an anatomical structure.

10. The apparatus according to claim 1, wherein the anatomical structure is a middle ear.

11. The apparatus according to claim 1, wherein the imaging information is associated with a sound wave frequency distribution of the sound wave.

12. A method for providing imaging information associated with at least one portion of a sample, comprising:

providing at least two first different wavelengths of at least one first electro-magnetic radiation within a first wavelength range provided on the at least one portion of the sample so as to determine at least one first transverse location of the portion;

providing at least two second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion;

obtaining a relative phase between at least one third electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, wherein the motion is effectuated by at least one of a sound wave; and

providing the imaging information of the portion based on the at least one first transverse location, the at least one second transverse location and the motion.

13. The method according to claim 12, wherein the sound wave includes an ultra-sound wave.

14. The method according to claim 12, wherein the sample is an anatomical structure.

15. The method according to claim 12, wherein the sample is at least one portion of a bone.

16. The method according to claim 12, wherein the sample is at least one portion of an ear.

17. The method according to claim 12, wherein the sound wave has a frequency of approximately 0.1 Hz to 10 kHz.

18. The method according to claim 12, wherein the sound wave has a frequency of approximately 100 Hz to 20 kHz.

19. The method according to claim 12, wherein the sound wave impacts the tympanic membrane of the sample.

20. The method according to claim 12, wherein the anatomical structure is a middle ear.

21. The method according to claim 12, wherein the imaging information is associated with a sound wave frequency distribution of the sound wave.