Pre-excitation pacing for treatment of hypertension
First Claim
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1. An implantable pacing device, comprising:
- pulse generating circuitry for outputting pacing pulses through one or more pre-excitation pacing channels each of which includes an electrode adapted for disposition near a myocardial site;
a controller programmed to deliver paces through the pre-excitation pacing channel(s) in accordance with a programmed pre-excitation pacing mode when the device is operating in a pre-excitation state;
a switch operable by the controller for configuring the pre-excitation pacing channel(s) with a pacing electrode selected among a plurality of pacing electrodes;
a blood pressure sensor communicating with the controller for generating a signal related to a patient'"'"'s arterial blood pressure, the controller being programmed to derive a blood pressure measurement therefrom;
wherein the controller is programmed to optimally configure the pre-excitation pacing channel(s) by sequentially reconfiguring the pre-excitation pacing channel(s) with different pacing electrodes and selecting the pacing electrode for use in the pre-excitation pacing channel(s) that results in the greatest decrease in the blood pressure measurement during delivery of pre-excitation pacing.
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Abstract
Described herein are methods and apparatus for treating hypertension with electrical pre-excitation pacing therapy. Electrical pre-excitation of a hypertrophic region advances the timing of the regional contraction and reduces its contribution to the overall contraction. Such pre-excitation pacing therapy may be beneficial to hypertensive patients with an abnormal distribution of ventricular wall stress/strain.
36 Citations
11 Claims
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1. An implantable pacing device, comprising:
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pulse generating circuitry for outputting pacing pulses through one or more pre-excitation pacing channels each of which includes an electrode adapted for disposition near a myocardial site; a controller programmed to deliver paces through the pre-excitation pacing channel(s) in accordance with a programmed pre-excitation pacing mode when the device is operating in a pre-excitation state; a switch operable by the controller for configuring the pre-excitation pacing channel(s) with a pacing electrode selected among a plurality of pacing electrodes; a blood pressure sensor communicating with the controller for generating a signal related to a patient'"'"'s arterial blood pressure, the controller being programmed to derive a blood pressure measurement therefrom; wherein the controller is programmed to optimally configure the pre-excitation pacing channel(s) by sequentially reconfiguring the pre-excitation pacing channel(s) with different pacing electrodes and selecting the pacing electrode for use in the pre-excitation pacing channel(s) that results in the greatest decrease in the blood pressure measurement during delivery of pre-excitation pacing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification