Selective neuromodulation using energy-efficient waveforms
First Claim
1. A method for selective neuromodulation in a live mammalian subject, comprising:
- selecting parameters for an energy-efficient waveform to selectively activate neural tissue; and
applying an electrical signal to a site in the nervous system of the subject, wherein the electrical signal comprises pulses having the energy-efficient waveform,wherein the energy-efficient waveform is more energy-efficient than a hypothetical pulse having a rectangular waveform but otherwise having the same parameter settings as the energy-efficient waveform.
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Abstract
Methods of selective neuromodulation in a live mammalian subject, such as a human patient. The method comprises applying an electrical signal to a target site in the nervous system, such as the brain, where the electrical signal comprises a series of pulses. The pulses includes a waveform shape that is more energy-efficient as compared to a corresponding rectangular waveform. Non-limiting examples of such energy-efficient waveforms include linear increasing, linear decreasing, exponential increasing, exponential decreasing, and Gaussian waveforms. The parameters for the energy-efficient waveform are chosen to selectively activate neural tissue on the basis of axonal diameter.
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Citations
24 Claims
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1. A method for selective neuromodulation in a live mammalian subject, comprising:
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selecting parameters for an energy-efficient waveform to selectively activate neural tissue; and applying an electrical signal to a site in the nervous system of the subject, wherein the electrical signal comprises pulses having the energy-efficient waveform, wherein the energy-efficient waveform is more energy-efficient than a hypothetical pulse having a rectangular waveform but otherwise having the same parameter settings as the energy-efficient waveform. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A neuromodulation apparatus, comprising:
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an electrode comprising an electrode contact; and an implantable pulse generator coupled to the electrode; wherein the pulse generator is programmed to apply an electrical signal to the electrode contact, the electrical signal comprising pulses having an energy-efficient waveform, wherein the energy-efficient waveform is more energy-efficient than a hypothetical pulse having a rectangular waveform but otherwise having the same parameter settings as the energy-efficient waveform.
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Specification