Nasal devices

• US 8,047,202 B2
• Filed: 12/19/2008
• Issued: 11/01/2011
• Est. Priority Date: 07/02/2002
• Status: Expired due to Term

• Current Assignee: OptiNose, Inc.
• Original Assignee: OptiNose AS (OptiNose, Inc.)
• Inventors: Djupesland, Per Gisle
• Primary Examiner(s): Yu; Justine
• Assistant Examiner(s): Matter; Kristen
• Application Number:
  US12/339,716
• Publication Number:
  US 20090101146A1
• Time in Patent Office: 1,047 Days
• Field of Search: 128/200.14, 128/200.21, 128/200.22, 128/203.12, 128/203.13, 128/203.15, 128/203.16, 128/203.18, 128/203.22, 128/206.11, 128/207.18
• US Class Current: 128/203.18
• CPC Class Codes: A61M 11/00 Sprayers or atomisers specially adapted for therapeutic purposes in general B05B; aerosol containers B65D83/14
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0051 the dosages being arranged on a tape, e.g. strips
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2202/04 Liquids
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2202/30 Vaccines
• CPC Class Codes: A61M 2209/06 Packaging for specific medical equipment
• CPC Class Codes: A61M 2209/088 on the body

Abstract

A nasal delivery device and a method of delivering substance to a nasal airway of a subject, can be used for mass treatment, especially mass vaccination. The delivery device can include an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device can also include an actuation unit for actuating the at least one delivery unit of the interface unit.

Claims

1. A nasal delivery device for delivering substance to a nasal airway of a subject, comprising:

a disposable interface unit, comprising at least one nosepiece unit for fitting to a respective nostril of a subject, each nosepiece unit comprising a nozzle from which substance is in use delivered, a mouthpiece into which the subject in use exhales, and at least one delivery unit comprising a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit; and

an actuation unit for actuating the at least one delivery unit of the interface unit in response to exhalation by the subject into the mouthpiece;

wherein the interface unit is disposable separately of the actuation unit.

2. The delivery device of claim 1, wherein the interface unit comprises a single integral unit.

3. The delivery device of claim 1, wherein the interface unit is packaged in protective packaging.

5. The delivery device of claim 1 or 4, wherein the substance supply unit comprises a substance pump unit for delivering substance, the substance pump unit including a chamber containing substance and a piston member which is movable in the chamber to deliver a flow of substance from the chamber, and wherein the substance comprises a liquid or a powder.

6. The delivery device of claim 1, wherein the mouthpiece is fluidly connected to the at least one nosepiece unit such as to provide an air flow therethrough on exhalation by the subject into the mouthpiece.

7. The delivery device of claim 1, wherein the at least one delivery unit includes a gas supply unit for supplying a gas flow through the at least one nosepiece unit, wherein the gas supply unit comprises a gas pump unit for delivering a gas flow, the gas pump unit comprising a cylinder and a piston member which is movable in the cylinder to deliver the gas flow through the at least one nosepiece unit, and wherein the at least one delivery unit is configured such that the gas supply unit initiates supply of the gas flow prior to actuation of the substance supply unit to deliver substance.

8. The delivery device of claim 1, wherein the actuation unit includes a gas supply unit for supplying a gas flow through the at least one nosepiece unit, and wherein the actuation unit is configured such that the gas supply unit initiates supply of the gas flow prior to actuation of the substance supply unit to deliver substance.

9. The delivery device of claim 1, wherein the actuation unit includes a detection unit for detecting exhalation by the subject, at least one drive unit for actuating the at least one delivery unit, and a control unit for actuating the at least one drive unit in response to detecting exhalation by the subject, and wherein the detection unit includes (i) a pressure sensor for detecting a pressure in the mouthpiece, and the control unit is configured to actuate the at least one drive unit in response to detection of a predeterminable pressure by the detection unit or (ii) a flow sensor for detecting a flow rate through the mouthpiece, and the control unit is configured to actuate the at least one drive unit in response to detection of a predeterminable flow rate by the detection unit.

10. The delivery device of claim 1, wherein the actuation unit includes at least one drive unit for actuating the at least one delivery unit, and a trigger mechanism for actuating the at least one drive unit in response to exhalation by the subject into the mouthpiece, and wherein the trigger mechanism is configured to actuate the at least one drive unit in response to generation of (i) a predeterminable pressure in the mouthpiece or (ii) a predeterminable flow rate through the mouthpiece.

11. The delivery device of claim 1, wherein the interface unit includes first and second nosepiece units for fitting to respective nostrils of the subject, and first and second delivery units, each including a substance supply unit for delivering substance through the respective nosepiece unit, and wherein the actuation unit is configured to actuate the first and second delivery units in succession such that substance is first delivered into one nasal cavity and subsequently into the other nasal cavity.

12. The delivery device of claim 1 or 4, comprising:

a plurality of interface units attached to a belt such as to allow for successive attachment of the interface units to the actuation unit, and wherein the actuation unit is configured successively to provide the interface units thereto through use of the belt as a guide.

4. A nasal delivery device for delivering substance to a nasal airway of a subject, comprising:

a disposable interface unit, comprising (i) first and second nosepiece units for fitting to respective nostrils of a subject, each nosepiece unit comprising a nozzle from which substance is in use delivered, and (ii) first and second delivery units, each delivery unit comprising a substance supply unit for delivering substance to the nozzle of the respective nosepiece unit; and

an actuation unit for actuating the delivery units of the interface unit in response to exhalation by the subject;

wherein the interface unit is disposable separately of the actuation unit.

13. The delivery device of claim 4, wherein the actuation unit is configured to actuate the first and second delivery units in succession such that substance is first delivered into one nasal cavity and subsequently into the other nasal cavity.

14. The delivery device of claim 4, wherein the interface unit further comprises a mouthpiece into which the subject in use exhales, and wherein the mouthpiece is fluidly connected to the at least one nosepiece unit such as to provide an air flow therethrough on exhalation by the subject into the mouthpiece.

15. The delivery device of claim 4, wherein the delivery units each include a gas supply unit for supplying a gas flow through the respective nosepiece units, wherein the gas supply unit comprises a gas pump unit for delivering the gas flow, the gas pump unit comprising a cylinder and a piston member which is movable in the cylinder to deliver the gas flow through the respective nosepiece units, and wherein the delivery units are configured such that the gas supply unit initiates supply of the gas flow prior to actuation of the substance supply unit to deliver substance.

16. The delivery device of claim 4, wherein the actuation unit includes a gas supply unit for supplying a gas flow through the nosepiece units, and wherein the actuation unit is configured such that the gas supply unit initiates supply of the gas flow prior to actuation of the substance supply unit to deliver substance.

17. The delivery device of claim 4, wherein the actuation unit includes a detection unit for detecting exhalation by the subject, first and second drive units for actuating the first and second delivery units, and a control unit for actuating the drive units in response to detecting exhalation by the subject, and wherein the detection unit includes (i) a pressure sensor for detecting a pressure, and the control unit is configured to actuate the drive units in response to detection of a predeterminable pressure by the detection unit or (ii) a flow sensor for detecting a flow rate, and the control unit is configured to actuate the drive units in response to detection of a predeterminable flow rate by the detection unit.

18. The delivery device of claim 4, wherein the actuation unit includes first and second drive units for actuating the first and second delivery units, and a trigger mechanism for actuating the first and second drive units in response to exhalation by the subject, and wherein the trigger mechanism is configured to actuate the drive units in response to generation of (i) a predeterminable pressure or (ii) a predeterminable flow rate.

19. The delivery device of claim 4, wherein the interface unit comprises a single integral unit.

20. The delivery device of claim 4, wherein the interface unit is packaged in protective packaging.