Medical articles incorporating surface capillary fiber

• US 8,048,042 B2
• Filed: 02/18/2004
• Issued: 11/01/2011
• Est. Priority Date: 07/22/2003
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Inventors: Hinnenkamp, Thomas F., Ogle, Matthew F.
• Primary Examiner(s): Mehta; Bhisma
• Application Number:
  US10/781,503
• Publication Number:
  US 20050021152A1
• Time in Patent Office: 2,813 Days
• Field of Search: 604/264, 604/265, 604/266, 604/269, 604/523
• US Class Current: 604/264
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing

Abstract

Medical devices are described that comprise surface capillary (SCF) fibers, which can impart desirable properties to the devices. For example, implantable prostheses are described comprising SCF fibers. In other embodiments, catheters are described having SCF fibers along the surface of the catheters. In addition, SCF fibers can be useful for the delivery of bioactive agents in association with the fibers. Due to the fluid flow capabilities of the fibers, medical devices are described that incorporate fiber matrices to facilitate blood delivery to cells within the structure.

Claims

1. A method for delivering a bioactive agent using a medical device, the method comprising

contacting a patient'"'"'s body fluids/tissues with a plurality of surface capillary fibers associated with at least a portion of a surface of the device, wherein the surface capillary fibers are pre-loaded and in association with a bioactive agent that elutes in a controlled way from the fibers upon contacting the fluids/tissues,

wherein each of the surface capillary fibers comprises at least one capillary along its outer surface running along at least a portion of the length of the surface capillary fiber,

wherein the medical device is a percutaneous device having the plurality of surface capillary fibers associated with a portion of the device to be placed within the patient, or is an implantable device, and

wherein the bioactive agent is associated with a controlled release agent.

2. The method of claim 1 wherein the medical device is a prosthetic device.

3. The method of claim 1 wherein the medical device is a catheter.

4. The method of claim 3 wherein the catheter comprises a lumen and the surface capillary fibers are associated with the lumen of the catheter.

5. The method of claim 1 wherein the bioactive agent is selected from the group consisting of a thrombolytic agent, an anti-platelet agent, an anti-coagulation agent, a growth factor or a combination thereof.

6. The method of claim 1 wherein the plurality of surface capillary fibers are associated with at least a portion of a surface of the device with an adhesive, mechanical binding, heat bonding, or chemical bonding.

7. The method of claim 1 wherein the bioactive agent is selected from a group consisting of an anti-microbial agent, a thrombolytic agent, an anti-platelet agent, an anti-coagulation agent, a growth factor or a combination thereof.

8. The method of claim 1 wherein the bioactive agent comprises a thrombolytic agent.

9. The method of claim 1 wherein the bioactive agent comprises tissue plasminogen activator.

10. The method of claim 1 wherein the bioactive agent comprises an anti-microbial agent.

11. The method of claim 1 wherein the device is configured for placement within a blood vessel without blocking flow through the vessel.

12. A medical device comprising:

a plurality of surface capillary fibers associated with at least a portion of a surface of the device, the surface capillary fibers comprising a polymer, and

a quantity of bioactive agent pre-loaded and in association with the surface capillary fibers,

wherein the bioactive agent elutes in a controlled way from the fibers when the surface capillary fibers are in contact with a patient'"'"'s body fluids/tissue,

wherein each of the surface capillary fibers comprises at least one capillary along its outer surface running along at least a portion of the length of the surface capillary fiber,

wherein the medical device is a percutaneous device or is an implantable device, and

wherein the bioactive agent is associated with a controlled release agent.

13. The medical device of claim 12 wherein the plurality of surface capillary fibers are associated with at least a portion of a surface of the device with an adhesive, mechanical binding, heat bonding, or chemical bonding.

14. The medical device of claim 12 wherein the bioactive agent is selected from a group consisting of an anti-microbial agent, a thrombolytic agent, an anti-platelet agent, an anti-coagulation agent, a growth factor or a combination thereof.

15. The medical device of claim 12 wherein the bioactive agent comprises a thrombolytic agent.

16. The medical device of claim 12 wherein the bioactive agent comprises tissue plasminogen activator.

17. The medical device of claim 12 wherein the bioactive agent comprises an anti-microbial agent.

18. The medical device of claim 12 wherein each of the surface capillary fibers has a surface area of at least about a factor of 1.5 greater than a corresponding circular fiber with an equivalent diameter.

19. The medical device of claim 12 wherein the device is configured for placement within a blood vessel without blocking flow through the vessel.

20. The medical device of claim 12 wherein the device comprises a catheter and additional surface capillary fibers, wherein the additional surface capillary fibers are associated with the inner surface of the catheter.

21. A medical device, comprising:

a plurality of surface capillary fibers associated with at least a portion of a surface of the device, the surface capillary fibers comprising a polymer matrix, and

a quantity of bioactive agent pre-loaded within the polymer matrix of the surface capillary fibers,

wherein the bioactive agent elutes in a controlled way from the fibers when the surface capillary fibers are in contact with a patient'"'"'s body fluids/tissue,

wherein each of the surface capillary fibers comprises at least one capillary along its outer surface running along at least a portion of the length of the surface capillary fiber, and wherein the medical device is a percutaneous device or an implantable device.

22. The medical device of claim 21 wherein the bioactive agent is selected from a group consisting of an anti-microbial agent, a thrombolytic agent, an anti-platelet agent, an anti-coagulation agent, a growth factor or a combination thereof.

23. The medical device of claim 21 wherein the bioactive agent comprises a thrombolytic agent.

24. The medical device of claim 21 wherein the bioactive agent comprises tissue plasminogen activator.

25. The medical device of claim 21 wherein the bioactive agent comprises an anti-microbial agent.