Degassing device and end-cap assembly for a filter including such a degassing device

• US 8,048,209 B2
• Filed: 11/02/2004
• Issued: 11/01/2011
• Est. Priority Date: 11/24/2003
• Status: Active Grant

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: Chevallet, Jacques, Ertl, Thomas, Goehl, Hermann, Ribolzi, Francesco, Dannenmaier, Jürgen
• Primary Examiner(s): Greene; Jason M
• Application Number:
  US10/595,772
• Publication Number:
  US 20090084720A1
• Time in Patent Office: 2,555 Days
• Field of Search: 96/4, 96/6, 96/8, 96/10, 96/11, 964/21, 95/46, 95/47, 95/51, 95/54, 555/10, 210/188, 210/321.6, 210/321.78, 210/321.8, 210/321.89, 604/4.01, 604/6.09, 604/126
• US Class Current: 96/6
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/3627 Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: B01D 2313/21 Specific headers, end caps

Abstract

A degassing device (203) comprises a first chamber (21) having an inlet for a liquid, and a second chamber (22) having an opening (23) closed by a hydrophobic membrane (24) and an outlet (25) for discharging the liquid. The first chamber (21) has a downstream portion that partially extends within the second chamber (22) and communicates therewith by a passageway (28). The second chamber (22) has a downstream portion that extends below the passageway (28) and asymmetrically surrounds the downstream portion of the first chamber (21).

Claims

1. A degassing device, comprising:

a first chamber having an inlet for a liquid; and

a second chamber having;

an opening closed by a hydrophobic membrane;

a liquid inlet port for the infusion of the liquid, and

an outlet for discharging the liquid,

wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, and the second chamber has a downstream portion that extends below the passageway and asymmetrically surrounds the downstream portion of the first chamber and

wherein the downstream portion of the second chamber has a first lateral wall surrounding a longitudinal axis of the degassing device and a bottom wall inclined with respect to the longitudinal axis.

2. A degassing device according to claim 1, wherein the lateral wall is a first lateral wall, and the downstream portion of the first chamber has a second lateral wall that is concentric to the first lateral wall of the second chamber.

3. A degassing device according to claim 2, wherein the second lateral wall of the downstream portion of the first chamber and the first lateral wall of the downstream portion of the second chamber are substantially cylindrical.

4. A degassing device according to claim 1, wherein the downstream portion of the first chamber has a cross-section that is substantially the same as a cross-section of the passageway between the first and the second chamber.

5. A degassing device according to claim 1, wherein the downstream portion of the first chamber is substantially conical and the passageway between the first and the second chamber opens at a top of the substantially conical downstream portion, and along a direction of flow.

6. A degassing device according to claim 5, wherein the passageway between the first and the second chamber opens along the direction of flow to the second chamber close to a wall delimiting an upstream portion of the second chamber.

7. A degassing device according to claim 1, wherein the first chamber comprises an upstream portion having a decreasing cross section.

8. A degassing device according to claim 1, wherein the first chamber comprises an upstream portion having an increasing cross section.

9. A degassing device according claim 1, wherein the second chamber comprises an upstream portion extending above the passageway that has a decreasing cross-section, with a larger cross-section that is substantially level with the passageway and a smaller cross-section that is substantially level with the hydrophobic membrane.

10. A degassing device according to claim 9, wherein the upstream portion of the second chamber is substantially frusto-conical.

11. A degassing device according to claim 1, wherein the outlet port opens in the downstream portion of the second chamber at a location furthest to the passageway.

12. A degassing device according to claim 1, wherein a ratio of a diameter of the passageway to a diameter of the second chamber at the level of the passageway is comprised between about 0.2 and about 0.5.

13. A degassing device according to claim 1, wherein the first chamber of the degassing device has a downstream portion having a cross-section selected with respect to a maximal flow rate of a liquid in a circuit connected to the degassing device so that a velocity of the liquid in the downstream portion of the first chamber is less than a predetermined velocity.

14. A degassing device according to claim 13, wherein the cross-section of the downstream portion of the first chamber is selected with respect to a maximal flow rate of a liquid of about 500 mL/min in a circuit connected to the degassing device so that the velocity of the liquid in the downstream portion of the first chamber is less than about 3 ml/min.

15. A degassing device according to claim 1, wherein a cross-section of the second chamber of the degassing device at the level of the passageway is selected so that a ratio of a velocity of a liquid within a downstream portion of the first chamber to a velocity of the liquid within the second chamber at the level of the passageway is more than a determined value.

16. A degassing device according to claim 15, wherein the cross-section of the second chamber of the degassing device at the level of the passageway is selected so that the ratio of the velocity of the liquid within the downstream portion of the first chamber to the velocity of the liquid within the second chamber at the level of the passageway is at least about 2.

17. A degassing device according to claim 1, wherein the downstream portion of the second chamber forms an overflow for a fluid flowing from the first chamber into the second chamber.

18. A degassing device according to claim 1, wherein the first chamber, the second chamber and the passageway therebetween are arranged with respect to each other so that a flow pattern of a liquid flowing from the first chamber, through the second chamber and to the outlet comprises a component that is tangential to the membrane.

19. A degassing device according to claim 18, wherein the flow pattern of the liquid flowing from the first chamber, through the second chamber and to the outlet comprises an umbrella-like component.

20. A degassing device according to claim 1, wherein the first chamber, the second chamber and the passageway therebetween are arranged with respect to each other so that a flow of liquid flowing from the first chamber, through the second chamber and to the outlet keeps gas bubbles in motion along an inner surface of the hydrophobic membrane.

21. A degassing device according to claim 1, further comprising:

a pressure measurement port for connection to a pressure sensor.

22. A degassing device according to claim 1, further comprising:

a protective member for protecting the hydrophobic membrane against external blows and for limiting a deformation of the hydrophobic membrane when a pressure of the liquid within the degassing device exceeds a limit.

23. A degassing device according to claim 1, wherein the hydrophobic membrane is arranged in a plane substantially perpendicular to a longitudinal axis of the degassing device.

24. An end-cap assembly for a filtration device including a filtration membrane arranged in an elongated housing, the end-cap assembly, comprising:

an end-cap having;

an end wall having a central axis, and

a peripheral wall surrounding the end wall for connection to an end of the housing, and

a degassing device according to claim 1 connected to the end-cap so that the first chamber of the degassing chamber is in fluid communication with an interior of the end-cap.

25. An end-cap assembly according to claim 24, wherein the degassing device has a longitudinal axis that coincides with the central axis of the end wall of the end-cap and the first chamber has a wall directly connected to the end wall of the end-cap.

26. An end-cap assembly according to claim 25, wherein the end wall of the end-cap is substantially annular and the wall of the first chamber has a circular cross section decreasing from a first end of larger section, by which the first chamber is connected to the end wall of the end cap, to a second end of smaller cross section forming the passageway between the first chamber and the second chamber.

27. An end-cap assembly according to claim 24, wherein the degassing device has a longitudinal axis that is substantially parallel to and spaced apart from the central axis of the end wall of the end-cap, and

the end cap assembly further comprises:

a lateral nozzle for connecting an interior of the end-cap to an inlet of the first chamber of the degassing device.

28. An end-cap assembly according to claim 27, wherein the first chamber has a wall having a circular cross section increasing from a first end of smaller section, which forms the inlet of the first chamber, to a second end of larger cross section, which forms the passageway between the first and the second chambers.

29. A filtration device, comprising:

an elongated housing;

a filtration membrane arranged in the elongated housing; and

an end-cap assembly connected to the elongated housing, the end-cap assembly comprising;

an end-cap having;

an end wall having a central axis,

a peripheral wall surrounding the end wall for connection to an end of the housing, and

a degassing device according to claim 1 connected to the end-cap so that the first chamber of the degassing chamber is in fluid communication with an interior of the end-cap.

30. A filtration device according to claim 29, wherein the device is for extracorporeal treatment of blood.

31. A degassing device, comprising:

a first chamber having an inlet for a liquid; and

a second chamber having;

an upper opening closed by a hydrophobic membrane; and

an outlet for discharging the liquid, wherein the outlet is at a higher elevation than the inlet of the first chamber,

wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, the second chamber has a downstream portion that extends below the passageway and asymmetrically surrounds the downstream portion of the first chamber, wherein the outlet is in the downstream portion;

the downstream portion has a lateral wall that surrounds a longitudinal axis of the first chamber and the downstream portion has a bottom wall that is inclined with respect to a longitudinal axis of the degassing device.

32. A degassing device, comprising:

a first chamber having an inlet for a liquid; and

a second chamber having;

an upper opening closed by a hydrophobic membrane;

an outlet for discharging the liquid, wherein the outlet is at a higher elevation than the inlet of the first chamber; and

a wall delimiting the second chamber from the first chamber,

wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway that opens in the second chamber close to an upper rim of the wall, the downstream portion of the first chamber is substantially frusto-conical, and the second chamber has a downstream portion that extends below the passageway and asymmetrically surrounds the downstream portion of the first chamber, and the outlet is in the downstream portion of the second chamber.

39. A degassing device according to claim 32, wherein the upper rim of the wall is entirely in a plane substantially perpendicular to a longitudinal axis of the degassing device.

33. A degassing device, comprising:

a first chamber having an inlet for a blood liquid; and

a second chamber having;

an opening closed by a hydrophobic membrane; and

an outlet for discharging the blood liquid, at an elevation above the elevation of the first chamber;

wherein the first chamber has a downstream portion that partially extends within an upstream portion of the second chamber and communicates therewith by a passageway, the upstream portion of the second chamber extends above the passageway and has a decreasing cross-section, with a larger cross-section that is substantially level with the passageway and a smaller cross-section that is substantially level with the hydrophobic membrane, and the second chamber has a downstream portion which includes the outlet and that extends below the passageway and asymmetrically surrounds the downstream portion of the first chamber.

34. A degassing devices, comprising:

a first chamber having an inlet for a liquid; and

a second chamber having;

an opening closed by a hydrophobic membrane; and

an outlet for discharging the liquid, which is at a higher elevation than the inlet,

wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, and a ratio of a diameter of the passageway to a diameter of the second chamber at a level of the passageway is comprised between about 0.2 and about 0.5.

35. A degassing devices, comprising:

a first chamber having an inlet for a liquid; and

a second chamber having;

an opening closed by a hydrophobic membrane; and

a liquid inlet to receive another liquid to mix with the liquid in the second chamber;

an outlet for discharging the liquid, at a higher elevation than the inlet to the first chamber;

wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, and the downstream portion of the first chamber has a cross-section selected with respect to a maximal flow rate of a liquid in a circuit connected to the degassing device so that a velocity of the liquid in the downstream portion of the first chamber is less than a predetermined velocity.

36. A degassing device, comprising:

a first chamber having an inlet for a liquid; and

a second chamber having;

an opening closed by a hydrophobic membrane;

a liquid inlet to receive another liquid to mix with the liquid in the second chamber, and

an outlet for discharging the liquid, which is at a higher elevation than the inlet to the first chamber;

wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, and a cross-section of the second chamber of the degassing device at the level of the passageway is selected so that a ratio of a velocity of a liquid within a downstream portion of the first chamber to a velocity of the liquid within the second chamber at a level of the passageway is more than a determined value.

37. A degassing device, comprising:

a first chamber having an inlet for a liquid; and

a second chamber having;

an opening closed by a hydrophobic membrane; and

an outlet for discharging the liquid, which is at a higher elevation than the inlet of the first chamber;

wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, the second chamber has a downstream portion that extends below the passageway and asymmetrically surrounds the downstream portion of the first chamber, and the first chamber, the second chamber and the passageway therebetween are arranged with respect to each other so that a flow pattern of a liquid flowing from the first chamber, through the second chamber and to the outlet comprises a component that is tangential to the membrane.

38. A degassing device, comprising:

a first chamber having an inlet for a liquid; and

a second chamber having;

an opening closed by a hydrophobic membrane; and

an outlet for discharging the liquid, wherein the outlet is at a higher elevation than the inlet,

wherein the first chamber has a downstream portion that partially extends within the second chamber and communicates therewith by a passageway, and the first chamber, the second chamber and the passageway therebetween are arranged with respect to each other so that a flow of liquid flowing from the first chamber, through the second chamber and to the outlet port keeps gas bubbles in motion along an inner surface of the hydrophobic membrane.