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Polynucleotides encoding modified DNA cleavage enzymes and host cells therefor

  • US 8,048,664 B2
  • Filed: 11/18/2010
  • Issued: 11/01/2011
  • Est. Priority Date: 11/21/2003
  • Status: Active Grant
First Claim
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1. A composition, comprising:

  • an isolated polynucleotide encoding a variant T7 Endo I polypeptie having endonuclease activity, wherein the variant T7 Endo I polypeptide comprises an amino acid sequence that differs from the amino acid sequence of its parent T7 Endo I polypeptide solely by one or more mutations in a β

    -bridge corresponding to amino acids 44-49 of SEQ ID NO;

    12.

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