Method and apparatus for eliminating interference in pulse oxygen measurement

• US 8,050,730 B2
• Filed: 09/18/2006
• Issued: 11/01/2011
• Est. Priority Date: 12/23/2005
• Status: Expired due to Fees

• Current Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd. (Excelsior Union Ltd.)
• Original Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd. (Excelsior Union Ltd.)
• Inventors: Zhang, Xu, Li, Xu, Li, Shunan
• Primary Examiner(s): Winakur; Eric
• Assistant Examiner(s): Liu; Chu Chuan (JJ)
• Application Number:
  US11/522,396
• Publication Number:
  US 20070149872A1
• Time in Patent Office: 1,870 Days
• Field of Search: 600/310, 600/322, 600/323, 600/336
• US Class Current: 600/336
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

The present invention discloses a method and apparatus for eliminating interference in pulse oxygen measurement. The method comprises the steps of: collecting a first wavelength light and a second wavelength light transmitting through the object to be measured and converting collected optic signals into electric signals to form a plethysmogram; processing the plethysmogram so as to normalize it, in order to decompose the normalized plethysmogram into a combination of an ideal plethysmogram and noise, and expand the ideal plethysmogram by using functions that can make up a complete orthonormal system; eliminating the noise in the plethysmogram through differential operation; and restoring the plethysmogram free of noise through integral operation for calculating oxygen saturation. The apparatus comprises a collecting module, a processing module, a noise eliminating module, and a restoring module. The method and apparatus suitable for the measurement of oxygen saturation under weak perfusion and movement conditions.

Claims

1. A method for eliminating interference in oxygen content measurement, comprising:

collecting a first wavelength light and a second wavelength light transmitting through an object to be measured, and converting collected signals into electric signals to form a plethysmogram;

normalizing the plethysmogram and decomposing the normalized plethysmogram into a combination of an ideal plethysmogram and a noise component and to expand the ideal plethysmogram by using functions that make up an orthonormal system;

eliminating the noise component in the plethysmogram by performing at least one differentiation operation upon the plethysmogram, in which the noise component comprises a first noise component caused by motion or movement of the object during the oxygen content measurement, and a constant corresponding to the first noise component is generated by performing the at least one differentiation operation;

and restoring the plethysmogram without the noise component through an integration operation.

2. The method of claim 1, further comprising:

conducting an analog-to-digital conversion to the electric signals to form a digitalized plethysmogram for subsequent processing.

3. The method of claim 1, further comprising:

performing curve fitting to eliminate a nonlinear slow baseline drift and subsequently calculating oxygen saturation, the action of fitting further comprising;

computing one or more respective drift baseline fitting curve coefficient matrices according to at least one or more sampling frequencies and one or more sampling sequences of a transmitted light intensity of the first wavelength light and the second wavelength light; and

subtracting one or more corresponding fitting curves from plethysmogram waveform curves of the first wavelength light and second wavelength light.

4. The method of claim 1, wherein the action of normalizing the plethysmogram comprises expanding the ideal plethysmogram by using one or more trigonometric functions that make up an orthonormal system.

5. The method of claim 1, wherein the action of eliminating the noise component comprises:

differentiating the plethysmogram having been processed, and

normalizing the plethysmogram that has been differentiated to eliminate a baseline drift noise caused by movement.

6. The method of claim 1, wherein the action of eliminating the noise component comprises:

differentiating the plethysmogram having been processed to transform the noise component caused by abrupt extrusion of an object to be measured into an impulse-function in a form of a δ

function; and

conducting a three-point or five-point median filtering to eliminate the noise component.

7. The method of claim 1, wherein the action of eliminating the noise component comprises:

differentiating the plethysmogram having been processed to transform the noise component caused by mutation of a sampled value into positive and negative double impulse functions, and

conducting a five-point median filtering to eliminate the noise component.

8. The method of claim 3, wherein the oxygen saturation calculation is carried out by an area integration recursive algorithm, comprising:

integrating the plethysmogram having been restored in a period of time to eliminate a white noise occurring in the period of time and to obtain a ratio between a first AC component of the first wavelength light and a second AC component of the second wavelength light;

introducing a factor λ

to determine the ratio according to a formula listed below after a number of iterations;

9. The method of claim 8, wherein the period of time ranges from 2 to 3 seconds, and the factor comprises a value being in a range of 0<

λ

<

1.

10. The method of claim 9, wherein the value is 0.8.

11. The method of claim 1, wherein the first wavelength light and the second wavelength light comprises a red light and an infrared light respectively.

12. An apparatus for eliminating interference in pulse oxygen measurement, comprising:

a collecting module including a luminotron and a corresponding phototube that is adapted to collect a first wavelength light and a second wavelength light transmitting through an object to be measured and is adapted to convert collected signals into electric signals to form a plethysmogram;

a processing module that is adapted to normalize the plethysmogram and decompose the plethysmogram into a combination of an ideal plethysmogram and a noise component and is adapted to expand the ideal plethysmogram by using at least functions that make up an orthonormal system;

a noise eliminating module that is adapted to eliminate the noise component in the plethysmogram through at least a differentiation operation including a differential operator, in which

the noise component comprises a first noise component caused by motion or movement of the object during the oxygen content measurement, and a constant corresponding to the first noise component is generated by performing the at least one differentiation operation;

and a restoring module that is adapted to restore the plethysmogram without the noise component through an integral operation.

13. The apparatus of claim 12, further comprising:

a converting module that is adapted to perform analog-to-digital conversion of the electric signals to form a digitalized plethysmogram.

14. The apparatus of claim 12, further comprising:

a fitting module that is adapted to compute respective drift baseline fitting curve coefficient matrices according to at least one or more sampling frequencies and one or more sampling sequences of an intensity of the first wavelength light and an intensity of the second wavelength light and is adapted to subtract corresponding fitting curves from plethysmogram waveform curves of the first wavelength light and the second wavelength light to eliminate a nonlinear baseline drift.

15. The apparatus of claim 14, wherein at least one of the fitting module, the processing module, the noise eliminating module, and the restoring module comprises either a physical module or a computer-executable software module.

16. The apparatus of claim 12, wherein the functions that make up the orthonormal system comprise trigonometric functions.

17. The apparatus of claim 12, wherein the noise eliminating module is adapted to execute the following functions:

differentiating the plethysmogram having been processed by using the processing module, and

normalizing the plethysmogram that has been differentiated to eliminate a baseline drift noise caused by movement.

18. The apparatus of claim 12, wherein the noise eliminating module is adapted to execute the following functions:

differentiating the plethysmogram having been processed by the processing module to transform the noise component caused by abrupt extrusion of the object to be measured into an impulse function in a form of a δ

function; and

conducting a three-point or five-point median filtering to eliminate the noise component.

19. The apparatus of claim 12, wherein the noise eliminating module is adapted to execute the following functions:

differentiating the plethysmogram having been processed by the processing module to transform the noise component caused by mutation of a sampled value into positive and negative double impulse functions; and

conducting a five-point median filtering to eliminate the noise component.

20. The apparatus of claim 12, wherein the first wavelength light and the second wavelength light comprise a red light and an infrared light respectively.