Methods for treating and/or collecting information regarding neurological disorders, including language disorders

• US 8,050,767 B2
• Filed: 11/05/2007
• Issued: 11/01/2011
• Est. Priority Date: 12/09/2002
• Status: Active Grant

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Sheffield, W. Douglas, Pascual-Leone, Alvaro
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Stice; Paula J
• Application Number:
  US11/935,135
• Publication Number:
  US 20080146959A1
• Time in Patent Office: 1,457 Days
• Field of Search: 607/45, 600544-545
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

Methods for treating and/or collecting information regarding neurological disorders, including language disorders, are disclosed. A method in accordance with one embodiment directing a patient to perform a language-based task, directing information to be collected, with the information corresponding to a level of neural activity in the patient'"'"'s brain while the patient performs the language-based task, and, based at least in part on the information, selecting a stimulation site within the patient'"'"'s skull for receiving an electrode coupleable to an electrical current. In further embodiments, at least one electrode can be placed at the stimulation site, and the patient'"'"'s language disorder can be reduced by applying electrical stimulation directly to the stimulation site via the at least one electrode.

Claims

1. A method for treating a language disorder of a patient, comprising:

selecting multiple stimulation sites of a patient'"'"'s brain to include at least one from a first group of Broca'"'"'s area or Wernicke'"'"'s area, and at least one from a second group of the middle frontal gyrus, inferior frontal gyrus or inferior frontal lobe, the stimulation sites being located within the patient'"'"'s skull;

positioning at least one electrode epidurally or subdurally on, adjacent to or juxtaposed a stimulation site from the first group;

positioning at least one electrode epidurally or subdurally on, adjacent to or juxtaposed a stimulation site from the second group;

coupling the electrodes to a source of electrical potential; and

at least reducing a language disorder of the patient by applying electrical stimulation directly to the stimulation sites via the electrodes.

2. The method of claim 1, further comprising selectively activating and deactivating at least one of the electrodes based at least in part on patient response to the electrical stimulation.

3. The method of claim 1, further comprising:

directing the patient to perform a language-based task;

directing information to be collected, the information corresponding to a level of neural activity in the patient'"'"'s brain while the patient performs the language-based task; and

selecting the stimulation sites based at least in part on the information.

4. The method of claim 3 wherein directing the patient to perform a language-based task includes directing the patient to perform a task that requires no verbal output.

5. The method of claim 3 wherein directing the patient to perform a language-based task includes directing the patient to generate a verb associated with a common noun.

6. The method of claim 3 wherein directing the patient to perform a language-based task includes directing the patient to repeat a noun.

7. The method of claim 3 wherein directing the patient to perform a language-based task includes directing the patient to retrieve a word based on a letter cue.

8. The method of claim 3 wherein directing the patient to perform a language-based task includes directing the patient to retrieve a word based on a visual cue.

9. The method of claim 3 wherein directing the patient to perform a language-based task includes directing the patient to respond nonverbally to an oral task that requires the patient to understand the difference between two auditory commands.

10. The method of claim 1, further comprising:

administering a neuroexcitatory drug to the patient; and

applying the electrical stimulation while the neuroexcitatory drug is active in the patient'"'"'s body.

11. The method of claim 1 wherein stimulation parameters are used such that the electrical stimulation is applied to the stimulation sites from the first and second group simultaneously.

12. The method of claim 1 wherein stimulation parameters are used such that the electrical stimulation is applied to the stimulation sites from the first and second group randomly or pseudo-randomly.

13. The method of claim 1 wherein stimulation parameters are used such that the electrical stimulation that is applied to the stimulation sites from the first and second group is independently controlled.

14. A method for treating a language disorder of a patient, comprising:

identifying a patient as having a language disorder;

based at least in part on identifying the patient as having a language disorder, selecting a first stimulation site at the right hemisphere of a patient'"'"'s brain and selecting a second stimulation site at the left hemisphere of the patient'"'"'s brain, the stimulation sites being located within the patient'"'"'s skull;

positioning at least one electrode at each of the stimulation sites;

coupling the electrodes to a source of electrical potential; and

at least reducing a language disorder of the patient by applying electrical signals directly to the stimulation sites via the electrodes, the electrical signals including inhibitory signals applied to one of the first and second stimulation sites, and facilitatory signals applied to the other of the first and second stimulation sites.

15. The method of claim 14 wherein applying electrical signals includes applying inhibitory signals to the first stimulation site and facilitatory signals to the second stimulation site.

16. The method of claim 14 wherein applying electrical signals includes applying inhibitory signals to the second stimulation site and facilitatory signals to the first stimulation site.

17. The method of claim 14, further comprising making a determination that recruiting neurons at the one stimulation site is detrimental to the patient'"'"'s ability to recover a language based functionalilty, and wherein applying inhibitory signals to the one stimulation site and facilitatory signals to the other stimulation site is based at least in part on the determination.

18. The method of claim 14 wherein the second stimulation site is one of multiple second stimulation sites, and wherein the method further comprises selecting at least one of the second stimulation sites to include at least one from the group of Broca'"'"'s area and Wernicke'"'"'s area, and selecting at least another of the second stimulation sites to include at least one from the group of the middle frontal gyrus, inferior frontal gyrus and inferior frontal lobe.