Trajectory-based deep-brain stereotactic transcranial magnetic stimulation
First Claim
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1. A method for generating higher magnetic-field stimulation at a deep brain target than at more superficial cortical non-target brain regions, the method comprising the steps of:
- selecting a deep brain target,positioning an array of electromagnets about a patient'"'"'s head,orienting the electromagnets so that components of magnetic-field energy from at least two of the electromagnets intersect at the deep brain target, wherein the deep brain target is deeper in the brain and further from the electromagnets than the more superficial cortical non-target brain regions; and
simultaneously energizing at least two of the electromagnets, whereby a stimulating vector component of the magnetic field received at the deep brain target produces stimulation at the deep-brain target which is greater than that produced at the more superficial cortical brain locations between the deep brain target and the electromagnets.
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Abstract
The present invention provides for Stereotactic Transcranial Magnetic Stimulation (sTMS) at predetermined locations with the brain or spinal cord and incorporates an array of electromagnets arranged in a specified configuration where selected coils in the array are pulsed simultaneously. Activation of foci demonstrated by functional MRI or other imaging techniques can be used to locate the neural region affected. Imaging techniques can also be utilized to determine the location of the designated targets.
110 Citations
31 Claims
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1. A method for generating higher magnetic-field stimulation at a deep brain target than at more superficial cortical non-target brain regions, the method comprising the steps of:
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selecting a deep brain target, positioning an array of electromagnets about a patient'"'"'s head, orienting the electromagnets so that components of magnetic-field energy from at least two of the electromagnets intersect at the deep brain target, wherein the deep brain target is deeper in the brain and further from the electromagnets than the more superficial cortical non-target brain regions; and simultaneously energizing at least two of the electromagnets, whereby a stimulating vector component of the magnetic field received at the deep brain target produces stimulation at the deep-brain target which is greater than that produced at the more superficial cortical brain locations between the deep brain target and the electromagnets. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method for generating higher magnetic-field stimulation at a deep brain target than at more superficial cortical non-target brain regions, the method comprising the steps of:
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selecting a deep brain target; positioning an array of electromagnets about a patient'"'"'s head; orienting the electromagnets to deliver components of magnetic-field energy from at least two of the electromagnets to the deep brain target wherein the deep brain target is deeper in the brain and further from the electromagnets than the more superficial cortical non-target brain regions; and energizing at least two of the electromagnets, whereby the combined magnetic-field energy emitted from the at least two electromagnets stimulates the deep brain target more that it stimulates the non-target brain regions located between the deep brain target and the electromagnets. - View Dependent Claims (26)
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27. A method for generating higher magnetic-field stimulation at a deep brain target than at more superficial cortical non-target brain regions, the method comprising the steps of:
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selecting a deep brain target; positioning an array of electromagnets about a patient'"'"'s head; orienting the electromagnets so that components of magnetic-field energy from at least two of the electromagnets intersect at the deep brain target to deliver magnetic-field energy components to the deep brain target wherein the deep brain target is deeper in the brain and further from the electromagnets than the more superficial cortical non-target brain regions; and simultaneously energizing at least two of the electromagnets, whereby a stimulation from the electromagnets that is received at the deep brain target is greater than that received at the more superficial non-target brain regions located between the deep brain target and the electromagnets. - View Dependent Claims (28)
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29. A method for generating magnetic-field stimulation more intensely at a deep brain target than at more superficial non-target regions of the brain, the method comprising the steps of:
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positioning an array of electromagnets about a patient'"'"'s head; orienting the electromagnets so that components of magnetic-field energy from at least two of the electromagnets intersect at the deep brain target to deliver magnetic-field energy to a deep brain target wherein the deep brain target is deeper in the brain and further from the electromagnets than the more superficial non-target brain regions; and simultaneously energizing at least two of the electromagnets from different positions about the patient'"'"'s head to stimulate the deep brain target with a magnetic field at the target that is greater than the magnetic field received at the non-target brain regions located more superficially, between the deep brain target and the electromagnets.
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30. A method for generating higher stimulation at a deep brain target within the brain than at more superficial cortical non-target brain regions, the method comprising the steps of:
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selecting a deep brain target; positioning an array of electromagnets about a patient'"'"'s head in a non-overlapping arrangement so that none of the electromagnets is interposed between another electromagnet and the patient'"'"'s head, wherein the array of electromagnets is oriented so that components of magnetic-field energy from at least two of the electromagnets intersect at the deep brain target to deliver magnetic-field energy to the deep brain target; and simultaneously energizing at least two of the electromagnets to emit magnetic energy, whereby the energy received at the deep brain target produces stimulation at the deep-brain target which is greater than that produced at the more superficial cortical non-target brain locations between the deep brain target and the electromagnets. - View Dependent Claims (31)
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Specification