Multimodal catheter system and method for intravascular analysis

• US 8,052,605 B2
• Filed: 05/07/2009
• Issued: 11/08/2011
• Est. Priority Date: 05/07/2008
• Status: Active Grant

• Current Assignee: Infraredx Incorporated (Nipro Corporation)
• Original Assignee: Infraredx Incorporated (Nipro Corporation)
• Inventors: Wilder, Mark A., Muller, James E.
• Primary Examiner(s): Casler; Brian
• Assistant Examiner(s): Lamprecht; Joel
• Application Number:
  US12/437,022
• Publication Number:
  US 20090299195A1
• Time in Patent Office: 915 Days
• Field of Search: 600/462, 600/463, 600/439, 600/467, 600/459, 600/454, 600/450, 600/471, 604/22, 604/523, 606/159
• US Class Current: 600/439
• CPC Class Codes: A61B 5/0035 adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4416 related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
• CPC Class Codes: A61B 8/4461 Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe

Abstract

Methods, apparatus, and systems for intravascular analysis combine at least three analytical modalities. In one implementation, intravascular ultrasound, optical coherence tomography, and near infrared spectroscopy are combined to enable detection of multiple, different abnormalities in the arterial morphology during a single intravascular procedure.

Claims

1. An intravascular catheter system comprising:

a catheter comprising;

at least one optical fiber configured to transmit optical radiation between distal and proximal ends thereof,

an optical bench disposed at the distal end of said optical fiber and configured to direct light transmitted from said optical fiber to an arterial wall and to direct light scattered or reflected by the arterial wall into said optical fiber; and

an ultrasound transducer configured to transmit ultrasound energy toward the arterial wall, receive ultrasound energy reflected from the arterial wall, and convert the received ultrasound energy to an electric signal

a pull back and rotation system operatively coupled to said catheter and configured to impart rotational movement of said catheter about a longitudinal axis of said catheter and axial movement of said catheter along the longitudinal axis of said catheter;

a slip ring/ fiber optic rotary joint (FORJ) assembly including a rotating portion coupled to said catheter and a non-rotating portion and configured to couple electrical signals and optical signals between said rotating and non-rotating portions thereof;

at least one non-rotating source of optical radiation optically coupled to a portion of said optical fiber through said slip ring/FORJ assembly and configured to generate optical radiation to be transmitted by said optical fiber to the arterial wall through said optical bench;

an optical detector disposed on the rotating portion of said slip ring/FORJ assembly and optically coupled to said optical fiber and configured to receive optical radiation transmitted by said optical fiber from the arterial wall and convert the received optical signals to electrical signals that are transmitted over said slip ring/FORJ assembly to a computer to provide spectroscopic data about the arterial wall;

an ultrasound transceiver coupled to said ultrasound transducer and including drive electronics for driving said ultrasound transducer and configured to receive response signals from said ultrasound transducer and convert the received response signals to electronic signals that are transmitted to a computer to provide ultrasound image data for the arterial wall;

a non-rotating interferometer optically coupled to said optical fiber via said slip ring/FORJ assembly and configured to receive optical radiation transmitted by said optical fiber from the arterial wall and to provide an interference signal for sub-surface image data for the arterial wall; and

a user interface configured to present one or more representations of the morphological and chemical structure of the arterial walls based on the spectroscopic data from said optical detector, the ultrasound image data from said ultrasound transceiver, and sub-surface image data from said interferometer.

2. The intravascular catheter system of claim 1, wherein said at least one optical fiber comprises a delivery fiber and a collection fiber and wherein said at least one source is optically coupled with a portion of said delivery fiber, said interferometer is optically coupled to a portion of said delivery fiber and configured to receive optical radiation transmitted by said delivery fiber from the arterial wall, and said optical detector is optically coupled to a portion of said collection fiber and configured to receive optical radiation transmitted by said collection fiber from the arterial wall.

3. The intravascular catheter system of claim 2, wherein said delivery fiber is a single mode optical fiber configured to propagate only a single spatial mode and said collection fiber comprises a multimode fiber.

4. The intravascular catheter system of claim 1, wherein said optical bench comprises at least one reflector configured to redirect optical radiation from said distal end of said optical fiber toward the arterial wall and to redirect at least a portion of the optical radiation from the arterial wall toward said distal end of said fiber.

5. The intravascular catheter system of claim 1, wherein said at least one optical radiation source comprises one or both of a tunable laser and a super luminescent light emitting diode.

6. The intravascular catheter system of claim 1, wherein said ultrasound transducer is configured to employ time multiplexing to both transmit ultrasound energy toward the arterial wall and receive ultrasound energy from the arterial wall.

7. The intravascular catheter system of claim 1, further comprising one or more wires providing an electrical connection between said ultrasound transducer and said ultrasonic subsystem.

8. The intravascular catheter system of claim 1, wherein said catheter comprises an outer sheath covering at least a portion of said optical fiber.

9. The intravascular catheter system of claim 8, further comprising a guide wire coupled to a portion of said sheath and configured to guide movement of said sheath and said optical fiber through an intravascular lumen.

10. The intravascular catheter system of claim 1, further comprising a position detection system comprising an internal element configured to be inserted into an intravascular lumen along with said optical fiber and an external element disposed outside the intravascular lumen, wherein said internal element and said external element are configured for communication therebetween for locating a position of said internal element relative to said external element.

11. The intravascular catheter system of claim 1, wherein said at least one optical fiber and said ultrasound transducer comprise a catheter core, and wherein said system further comprises a torque cable coupled to said catheter core and configured to transmit a rotational force to a distal portion of said catheter core.

12. The intravascular catheter system of claim 1, wherein said ultrasound transducer is distally spaced from said distal end of said optical fiber.

13. The intravascular catheter system of claim 1, wherein said ultrasound transceiver is non-rotating.

14. The intravascular catheter system of claim 1, wherein said ultrasound transceiver is disposed on the rotating portion of said slip ring/FORJ assembly the electronic signals are transmitted over said slip ring/FORJ assembly from said ultrasound transceiver to the computer.