Medical devices and methods of making the same

• US 8,052,744 B2
• Filed: 09/13/2007
• Issued: 11/08/2011
• Est. Priority Date: 09/15/2006
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Girton, Timothy S.
• Primary Examiner(s): Sweet; Thomas J
• Assistant Examiner(s): Woznicki; Jacqueline
• Application Number:
  US11/855,019
• Publication Number:
  US 20080109072A1
• Time in Patent Office: 1,517 Days
• Field of Search: 623 138- 14, 623/1.42, 623 144- 145
• US Class Current: 623/1.39
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0023 differing in porosity
• CPC Class Codes: A61L 2/235 cellular, porous or foamed
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 2400/08 Methods for forming porous structures using a negative form which is filled and then removed by pyrolysis or dissolution
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 33/007 Porous materials, e.g. foams or sponges

Abstract

Medical devices, such as endoprostheses, and related methods are disclosed.

Claims

1. An endoprosthesis, comprising:

a generally tubular member having a lumen and including at least one component selected from the group consisting of struts, bands, and combinations thereof,

wherein the at least one component comprises a bioerodible material selected from the group consisting of bioerodible metals, bioerodible metal alloys, and combinations thereof, the bioerodible material defining a plurality of non-interconnected closed pores, and wherein the at least one component has a porous first region and a second porous region, the non-interconnected closed pores in the first region having a first average volume and the non-interconnected closed pores in the second region having a second average volume that is greater than the first average volume.

2. The endoprosthesis of claim 1, further comprising a polymer.

3. The endoprosthesis of claim 2, wherein the polymer is supported by the generally tubular member.

4. The endoprosthesis of claim 2, wherein the polymer is disposed within the first and/or second groups of said pores of the generally tubular member.

5. The endoprosthesis of claim 2, comprising a composite including a therapeutic agent and the polymer.

6. The endoprosthesis of claim 1, wherein the generally tubular member includes an exterior surface and an interior surface defining the lumen, and the first region of the at least one component defines at least a portion of the interior surface.

7. The endoprosthesis of claim 6, wherein the second region of the at least one component defines at least a portion of the exterior surface.

8. The endoprosthesis of claim 1, wherein the first region has a first pore density and the second region has a second pore density that is greater than the first pore density.

9. An endoprosthesis, comprising:

a generally tubular member comprising a bioerodible material selected from the group consisting of bioerodible metals, bioerodible metal alloys, and combinations thereof, the bioerodible material defining a plurality of non-interconnected closed pores, the generally tubular member having a first region defining an interior surface of the generally tubular member and a second region defining an exterior surface of the generally tubular member,

wherein the non-interconnected closed pores in the first region have a first average volume, and the non-interconnected closed pores in the second region having have a second average volume that is greater than the first average volume.

10. The endoprosthesis of claim 9, further comprising a polymer.

11. The endoprosthesis of claim 10, wherein the polymer is disposed within the first and/or second groups of said pores of the generally tubular member.

12. The endoprosthesis of claim 11, comprising a composite including a therapeutic agent and the polymer.

13. The endoprosthesis of claim 9, wherein the first region has a first pore density and the second region has a second pore density that is greater than the first pore density.