Multi-phasic nanoparticles

• US 8,052,849 B2
• Filed: 06/23/2010
• Issued: 11/08/2011
• Est. Priority Date: 11/10/2004
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Martin, David C., Roh, Kyung-Ho, Lahann, Joerg
• Primary Examiner(s): Mayes; Melvin Curtis
• Assistant Examiner(s): Qian; Yun
• Application Number:
  US12/821,688
• Publication Number:
  US 20110062608A1
• Time in Patent Office: 503 Days
• Field of Search: None
• US Class Current: 204/164
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C08J 2371/12 Polyphenylene oxides
• CPC Class Codes: C08J 3/12 Powdering or granulating
• CPC Class Codes: C08J 3/20 Compounding polymers with additives, e.g. colouring
• CPC Class Codes: C08J 3/246 Intercrosslinking of at least two polymers
• CPC Class Codes: D01D 5/0069 characterised by the spinning section, e.g. capillary tube, protrusion or pin
• CPC Class Codes: D01D 5/32 Side-by-side structure; Spinnerette packs therefor
• CPC Class Codes: D01F 8/00 Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
• CPC Class Codes: Y10S 977/906 Drug delivery

Abstract

A method of forming mufti-phasic nano-objects involves the jetting of two or more different liquids in side-by-side capillaries thereby generating a composite liquid stream. The composite then exposed to a force field which causes the composite liquid stream to at least partially solidify into a nano-object. The method forms a nano-object having a number of morphologies such as rods, spheres, and fibers.

Claims

1. A method of forming nano-objects, the method comprising:

combining two or more liquid streams together such that the two or more liquid streams contact over spatial dimensions sufficient to form a composite liquid stream; and

exposing at least a portion of the composite liquid stream to an electric force field sufficient to form a nano-sized cone jet that is fragmented and then the composite liquid stream is solidified to form the nano-objects, the nano-objects having a non-fibrous shape and comprising multiple phases and multiple chemically distinct exposed surface regions.

2. The method of claim 1 wherein the composite liquid stream is at least partially solidified by a solidification process selected from the group consisting of evaporation, sol-gel transitioning, cooling and combinations thereof.

3. The method of claim 1 wherein the composite liquid stream comprises a cone-jet.

4. The method of claim 1 wherein the composite liquid stream fragments into droplets when exposed to the force field.

5. The method of claim 1 wherein one or more of the liquid streams comprise a component selected from the group consisting of liquid solutions, curable polymer precursors, polymer solutions, polymer melts, and combinations thereof.

6. The method of claim 5 wherein one or more liquid streams further comprise an additive.

7. The method of claim 6 wherein the additive is selected from the groups consisting of inorganic nanocrystals, quantum dots, biomolecules, colorants, crosslinkers, pharmaceutical compounds, molecular probes, molecules that enable drug delivery, and combinations thereof.

8. The method of claim 7 further comprising curing one or more liquid streams comprising curable polymer precursors.

9. The method of claim 8 wherein the polymer precursors are cured thermally or by exposure to actinic radiation.

10. The method of claim 1 wherein the nano-object has a spatial dimension between about 20 nm and about 5,000 nm.

11. The method of claim 1 wherein the nano-object has a spatial dimension between about 20 nm and about 200 nm.

12. The method of claim 1 wherein the nano-object has a spatial dimension between about 50 nm and 500 nm.

13. The method of claim 1 wherein an electric field is formed by applying a potential difference between at least two electrodes from about 0.1 kV to about 25 kV.

14. The method of claim 1 wherein the two or more liquid streams each individually include a colorant and wherein the nano-object is a multiphase colorant.

15. The method of claim 1 wherein one or more liquid streams include one or more reactive components that react with a structural component thereby rendering a resulting surface of the nano-object chemically modified as compared to the surface when the one or more reactive components are not present.

16. A method of forming nano-objects, the method comprising:

combining two or more liquid streams together at a nozzle such that the two or more liquid streams contact over spatial dimensions sufficient to form a composite liquid stream having a nano-sized cone-jet; and

exposing at least a portion of the composite liquid stream to an electric field sufficient to fragment and then solidify the composite liquid stream into the nano-objects, the nano-objects comprising multiple phases and multiple chemically distinct exposed surface regions, wherein the nano-objects have a spatial dimension between about 20 nm and about 5,000 nm.

17. The method of claim 16 wherein one or more of the liquid streams comprise a component selected from the group consisting of liquid solutions, curable polymer precursors, polymer solutions, polymer melts, and combinations thereof.

18. A method of forming nano-objects comprising:

combining two or more liquid streams together at a nozzle such that the two or more liquid streams contact over spatial dimensions sufficient to form a composite liquid stream having a nano-sized cone-jet, wherein one or more of the liquid streams comprise a component selected from the group consisting of liquid solutions, curable polymer precursors, polymer solutions, polymer melts, and combinations thereof and one or more of the liquid streams further comprises an additive selected from the group consisting of inorganic nanocrystals, quantum dots, biomolecules, colorants, crosslinkers, pharmaceutical compounds, molecular probes, molecules that enable drug delivery, and combinations thereof; and

exposing at least a portion of the composite liquid stream to an electric field sufficient to fragment and then solidify the composite liquid stream into the nano-objects, the nano-objects having a non-fibrous shape and comprising multiple phases and multiple chemically distinct exposed surface regions.