Methods for fabricating coatings for drug delivery devices having gradient of hydration
First Claim
1. A method for fabricating a coating for an implantable medical device, the method comprising applying a first polymer on at least a portion of the device to form a first layer of the coating, and applying a second polymer on at least a portion of the first layer to form a second layer of the coating, wherein the second polymer has a higher degree of hydration than the first polymer, and wherein the first polymer or the second polymer comprises a polyorthoester.
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Abstract
A method for fabricating a coating for an implantable medical device is provided comprising applying a first polymer on at least a portion of the device to form a first layer of the coating and applying a second polymer on at least a portion of the first layer to form a second layer of the coating. The second polymer has a higher degree of hydration than the first polymer. The first or second polymer can comprise a polyorthoester.
155 Citations
49 Claims
- 1. A method for fabricating a coating for an implantable medical device, the method comprising applying a first polymer on at least a portion of the device to form a first layer of the coating, and applying a second polymer on at least a portion of the first layer to form a second layer of the coating, wherein the second polymer has a higher degree of hydration than the first polymer, and wherein the first polymer or the second polymer comprises a polyorthoester.
Specification