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Peptide conjugated, inosine-substituted antisense oligomer compound and method

  • US 8,053,420 B2
  • Filed: 03/31/2008
  • Issued: 11/08/2011
  • Est. Priority Date: 05/24/2004
  • Status: Active Grant
First Claim
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1. A method for enhancing the cellular uptake of a substantially uncharged antisense oligonucleotide compound, wherein the compound comprises a base sequence complementary to a string of at least four contiguous cytosine bases, the base sequence comprising one or more inosine bases and no more than three contiguous guanine bases, the method comprising forming a conjugate of the compound and an arginine-rich peptide.

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