Ion sensor for long term use in complex medium
First Claim
1. A method for detecting ischemia comprising:
- obtaining a differential electrical potential between an implanted electrode pair in a human body, the electrode pair including a first ion selective electrode (ISE) and a sodium ISE, wherein first ISE is a potassium ISE; and
employing an implanted medical device to generate an indication of ischemia at least in part as a function of a change in the differential electrical potential over time, wherein the change is a rise in a ratio of potassium to sodium over time.
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Abstract
Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
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Citations
6 Claims
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1. A method for detecting ischemia comprising:
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obtaining a differential electrical potential between an implanted electrode pair in a human body, the electrode pair including a first ion selective electrode (ISE) and a sodium ISE, wherein first ISE is a potassium ISE; and employing an implanted medical device to generate an indication of ischemia at least in part as a function of a change in the differential electrical potential over time, wherein the change is a rise in a ratio of potassium to sodium over time. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification