Apparatus for measuring an analyte in an eye fluid

• US 8,057,041 B2
• Filed: 07/23/2007
• Issued: 11/15/2011
• Est. Priority Date: 07/24/2006
• Status: Active Grant

• Current Assignee: EyeSense AG
• Original Assignee: EyeSense AG
• Inventors: Herbrechtsmeier, Peter, Gruler, Roman, Müller, Achim, Haberstroh, Klaus
• Primary Examiner(s): Pinkney; Dawayne
• Application Number:
  US12/374,772
• Publication Number:
  US 20100053556A1
• Time in Patent Office: 1,576 Days
• Field of Search: 351/219, 351/200, 351/205, 351246-247
• US Class Current: 351/219
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. The positioning system (122) comprises at least one of the following systems: a camera system, particularly a monocular or binocular camera system, having at least one camera (410; 910); an image recognition system; a triangulation system; a propagation time measuring system, particularly for 1-, 2- or 3-dimensional propagation time measurement, particularly using at least one laser and/or at least one phase mix detector (PMD); a 1-, 2- or 3-dimensional intensity measuring system for at least one signal; a 2- or 3-dimensional magnetoresistive measuring system.

Claims

1. A handheld measuring appliance for measuring at least one analyte in an eye fluid in an eye, having

a measuring system which is set up to measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property in at least one ocular sensor in the eye fluid, and

a positioning system which is set up to measure a three-dimensional positioning, wherein the three-dimensional positioning comprises a distance between at least one measurement location in the eye and the handheld measuring appliance and also at least one further positioning co-ordinate,

wherein the positioning system is selected from the group consisting of:

a camera system;

an image recognition system;

a triangulation system;

a propagation time measuring system;

a 1-, 2- or 3-dimensional intensity measuring system for at least one signal from a divergent electromagnetic and/or acoustic beam; and

a 2- or 3-dimensional magnetoresistive measuring system.

2. The handheld measuring appliance as claimed in claim 1, wherein the measuring system is selected from the group consisting of:

an infrared (IR) spectroscopic measuring system, a near infrared (NIR) spectroscopic measuring system, a RAMAN spectroscopic measuring system, a UV/visible (UV/VIS) spectroscopic measuring system, a fluorescence measuring system, an impedance measuring system, a photoacoustic measuring system, a circular dichroic measuring system, a refractometric measuring system, and an interferometric measuring system.

3. The handheld measuring appliance as claimed in claim 1, wherein the at least one further positioning co-ordinate is selected from the group consisting of:

an angle of a virtual connecting line between the handheld measuring appliance and the at least one measurement location in a prescribed angle system, a co-ordinate of the handheld measuring appliance, a co-ordinate of the at least one measuring location, and an orientation angle of the handheld measuring appliance in a prescribed co-ordinate system.

4. The handheld measuring appliance as claimed in claim 1, wherein the positioning system comprises a measuring system for comparing at least two signals measured by means of two sensors in a different spatial arrangement.

5. The handheld measuring appliance as claimed in claim 1, wherein the positioning system triggers a measurement by the measuring system when at least one prescribed nominal positioning or a prescribed nominal positioning range is reached.

6. The handheld measuring appliance as claimed in claim 1, wherein the positioning system sets a spatial position and/or spatial orientation of the measuring system.

7. The handheld measuring appliance as claimed in claim 6, wherein a piezo controller is provided for setting the spatial position and/or the spatial orientation of the measuring system.

8. The handheld measuring appliance as claimed in claim 1, wherein the positioning system and/or a feedback unit of the handheld measuring appliance are set up to generate at least one feedback signal for a user on the basis of the spatial positioning.

9. The handheld measuring appliance as claimed in claim 1, wherein the handheld measuring appliance is set up to determine the concentration of the at least one analyte in the eye fluid and/or in another body fluid.

10. The handheld measuring appliance as claimed in claim 9, wherein the handheld measuring appliance is set up to take account of the spatial positioning when determining the at least one analyte concentration.

11. The handheld measuring appliance as claimed in claim 9, having additionally a calibration system, wherein the calibration system is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.

12. An analytical measuring system for measuring at least one analyte in an eye fluid, comprising a handheld measuring appliance as claimed in claim 1 and also furthermore at least one ocular sensor which is suitable for being placed in contact with the eye fluid, wherein the at least one ocular sensor is designed to change at least one property upon contact with the at least one analyte, the at least one change of property being able to be measured using the measuring system.

13. The analytical measuring system as claimed in claim 12, wherein the at least one ocular sensor is selected from the group consisting of:

an eye lens; and

an eye implant.

14. The analytical measuring system as claimed in claim 12, wherein the at least one ocular sensor has at least one analyte receptor having at least one first fluorescence label and at least one analyte competitor having at least one second fluorescence label, wherein the at least one analyte receptor and the at least one analyte competitor are designed to change at least one property of the ocular sensor, when the at least one analyte competitor is bound to the at least one analyte receptor.

15. The analytical measuring system as claimed in claim 12, wherein the at least one ocular sensor has at least one grating and/or at least one hologram, wherein the at least one grating and/or the at least one hologram are designed to change at least one reflection property upon contact with the at least one analyte.

16. The analytical measuring system as claimed in claim 12, wherein the at least one ocular sensor furthermore has at least one reference fluorophor and/or reference colorant which is at least essentially uninfluencible by the at least one analyte.

17. The analytical measuring system as claimed in claim 12, wherein the at least one analyte is selected from the group consisting of:

glucose, and a hormone.

18. The analytical measuring system as claimed in claim 12, with additionally at least one positioning sensor, wherein the at least one positioning sensor is separate from the at least one ocular sensor or is part of the at least one ocular sensor and wherein the at least one positioning sensor is designed to generate at least one signal which can be detected by the positioning system.

19. The analytical measuring system as claimed in claim 18, wherein the at least one positioning sensor is selected from the group consisting of:

an eye lens; and

an eye implant.

20. The analytical measuring system as claimed in claim 18, wherein the at least one signal which can be detected by the positioning system is selected from the group consisting of:

a detectable shape or marker;

a fluorescence;

a magnetization;

a reference fluorescence signal; and

a reference color signal.

21. The handheld measuring appliance as claimed in claim 1, wherein the camera systems comprises a monocular or binocular camera system, having at least one camera.

22. The handheld measuring appliance as claimed in claim 1, wherein the propagation time measuring system, is for 1-, 2- or 3-dimensional propagation time measurement.

23. The handheld measuring appliance as claimed in claim 22, wherein the propagation time measuring system uses at least one laser and/or at least one phase mix detector (PMD).

24. The handheld measuring appliance as claimed in claim 9, wherein the body fluid is blood or tissue fluid.

25. The analytical measuring system as claimed in claim 13, wherein the eye lens is a contact lens.

26. The analytical measuring system as claimed in claim 19, wherein the eye lens is a contact lens.

27. The analytical measuring system as claimed in claim 14, wherein the at least one property of the ocular sensor is at least one fluorescence property.

28. A method for determining a concentration of at least one analyte in a body fluid using an analytical measuring system as claimed in claim 12, having the following steps:

a) positioning the handheld measuring appliance coarsely in front of the eye,

b) determining a spatial positioning,

c) triggering a measurement by the measuring system,

d) determining the concentration of the at least one analyte in the eye fluid from the at least one measured property of the at least one analyte and/or the at least one measured change of property of the at least one ocular sensor, and

e) converting the concentration of the at least one analyte in the eye fluid to a concentration of the at least one analyte in the body fluid by means of a prescribed conversion algorithm.

29. A computer program with program code for carrying out method steps b), c), d) and e) of the method as claimed in claim 28 when the program is executed on a computer or computer network.

30. The computer program as claimed in claim 29, with program code which is stored on a machine-readable medium.