Method for delivering therapeutic or diagnostic agents

• US 8,057,459 B2
• Filed: 01/12/2009
• Issued: 11/15/2011
• Est. Priority Date: 03/20/2003
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Rioux, Robert, DiCarlo, Paul
• Primary Examiner(s): STIGELL, THEODORE J
• Application Number:
  US12/352,393
• Publication Number:
  US 20090124998A1
• Time in Patent Office: 1,037 Days
• Field of Search: 604/20, 604/158, 604/500, 604506-508, 606/27
• US Class Current: 604/506
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0034 characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores making of catheters A61M25/0009
• CPC Class Codes: A61M 2025/0039 characterized by lumina being arranged coaxially
• CPC Class Codes: A61M 2025/0089 Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
• CPC Class Codes: A61M 25/003 characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves catheter tips A61M25/0067
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 5/329 characterised by features of the needle shaft
• CPC Class Codes: A61M 5/3291 Shafts with additional lateral openings

Abstract

An agent delivery device includes an inner tubular body having a proximal end, a sharpened distal end, a delivery lumen extending therebetween, and one or more outlet ports on the distal end communicating with the delivery lumen. The device also includes one or more seals sealing the one or more outlet ports, the one or more seals capable of being melted to allow a fluid to be delivered from the delivery lumen through the one or more outlet ports. The agent delivery device may further include a monopolar or bipolar electrode and/or a radio-opaque marker carried at the distal end of the device. The inner tubular body can be made from a conductive material to thereby allow the inner tubular body to function as an electrode.

Claims

1. A method for delivering an agent to a target site within tissue comprising:

advancing an elongate member into tissue containing the target site, the elongate member comprising a proximal end, a distal end, and a delivery lumen extending there between, and one or more outlet ports disposed on the distal end and communicating with the delivery lumen, the one or more outlet ports being sealed with respective seals to prevent leakage of fluid from the delivery lumen out the distal end of the elongate member;

applying heat to melt the respective seal(s) and unseal the one or more outlet ports; and

delivering the agent through the delivery lumen and out the one or more outlet ports.

2. The method of claim 1, wherein the respective seal(s) have a melting point of at least about 50°

C.

3. The method of claim 1, wherein the respective seal(s) have a melting point between about 70°

C. and about 100°

C.

4. The method of claim 1, wherein the applied heat is delivered by one or more electrodes configured to delivery radio frequency energy.

5. The method of claim 4, wherein the one or more electrodes are located on a separate elongate member.

6. The method of claim 1, wherein the applied heat is delivered by electrically resistive elements.

7. The method of claim 1, wherein the applied heat is delivered by a laser.

8. The method of claim 1, wherein the agent comprises a therapeutic agent.

9. The method of claim 1, wherein the agent comprises a diagnostic agent.

10. The method of claim 1, wherein the elongate member comprises a single outlet port and a single seal.

11. The method of claim 1, wherein at least one of the one or more outlet ports is disposed in a side wall of the elongate member.

12. A method for delivering an agent to a target site within tissue comprising:

advancing inner and outer elongate members into tissue containing the target site, the inner elongate member being moveable with respect of the outer elongate member, the inner elongate member comprising a proximal end, a distal end, and a delivery lumen extending there between, and one or more outlet ports disposed on the distal end and communicating with the delivery lumen, the one or more outlet ports being sealed with at least one seal to prevent leakage of fluid from the delivery lumen out the distal end of the inner elongate member;

advancing the inner elongate member relative to the outer elongate member to place the distal end within the target site;

applying heat to melt the at least one seal and unseal the one or more outlet ports; and

delivering the agent through the delivery lumen and out the one or more outlet ports.

13. The method of claim 12, further comprising creating a vacuum within a lumen formed between the inner and outer elongate members.

14. The method of claim 13, wherein the vacuum is created prior to delivering the agent through the delivery lumen and out the one or more outlet ports.

15. The method of claim 12, wherein the respective seal(s) have a melting point of at least about 50°

C.

16. The method of claim 12, wherein the respective seal(s) have a melting point between about 70°

C. and about 100°

C.

17. The method of claim 12, wherein the applied heat is delivered by one or more electrodes configured to delivery radio frequency energy.

18. The method of claim 17, wherein the one or more electrodes are located on the outer elongate member.

19. The method of claim 12, wherein the agent comprises a therapeutic agent.

20. The method of claim 12, wherein the agent comprises a diagnostic agent.

21. The method of claim 12, wherein the one or more outlets are sealed with a single seal.