Bioerodible endoprostheses and methods of making the same
First Claim
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1. An endoprosthesis, comprising:
- a plurality of struts, the plurality of struts comprising a plurality of generally circumferential struts being interconnected to one another or connected by one or more connecting struts, wherein at least one strut of the plurality of struts comprises a bioerodible magnesium or a bioerodible magnesium alloy, the at least one strut having a longest dimension extending in a z-axis, the at least one strut having a cross-section in an X-Y plane perpendicular to the z-axis, wherein the at least one strut has an initial geometry in the X-Y plane characterized by initial dimensions, andan erosion modifying material provided on the surface of the at least one strut which controls erosion to form a predetermined geometry such that, after erosion of at least about 50 percent of the area of the at least one strut in the X-Y plane, at least one initial dimension of the initial geometry is maintained in the X-Y plane.
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Abstract
A bioerodible endoprosthesis erodes to a desirable geometry that can provide, e.g., improved mechanical properties or degradation characteristics.
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Citations
23 Claims
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1. An endoprosthesis, comprising:
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a plurality of struts, the plurality of struts comprising a plurality of generally circumferential struts being interconnected to one another or connected by one or more connecting struts, wherein at least one strut of the plurality of struts comprises a bioerodible magnesium or a bioerodible magnesium alloy, the at least one strut having a longest dimension extending in a z-axis, the at least one strut having a cross-section in an X-Y plane perpendicular to the z-axis, wherein the at least one strut has an initial geometry in the X-Y plane characterized by initial dimensions, and an erosion modifying material provided on the surface of the at least one strut which controls erosion to form a predetermined geometry such that, after erosion of at least about 50 percent of the area of the at least one strut in the X-Y plane, at least one initial dimension of the initial geometry is maintained in the X-Y plane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 23)
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20. An endoprosthesis, comprising:
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a strut comprising a bioerodible magnesium or a bioerodible magnesium alloy, the strut having a longest dimension extending in a z-axis, the strut having a cross-section in an X-Y plane perpendicular to the z-axis, wherein the strut has an initial geometry in the X-Y plane characterized by initial dimensions, and an erosion modifying material provided on the surface of the strut which controls erosion to form an I-shape in the X-Y plane after erosion of at least about 50 percent of the area of the strut in the X-Y plane. - View Dependent Claims (21)
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22. An endoprosthesis, comprising:
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a plurality of struts, the plurality of struts comprising a plurality of generally circumferential struts being interconnected to one another or connected by one or more connecting struts, wherein at least one strut of the plurality of struts comprises a bioerodible magnesium or a bioerodible magnesium alloy, at least one strut having an initial geometry in X, Y, and Z directions, the at least one strut having a longest dimension extending in the Z direction, the X, Y, and Z directions each being perpendicular to each other; and an erosion modifying material provided on the surface of the at least one strut which controls erosion to form a predetermined geometry such that, after erosion of at least about 50 percent of the at least one strut, at least two initial dimensions in the X, Y, and Z directions are maintained.
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Specification