Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)

• US 8,057,742 B2
• Filed: 11/17/2009
• Issued: 11/15/2011
• Est. Priority Date: 08/18/2004
• Status: Active Grant

• Current Assignee: Vero Biotech LLC
• Original Assignee: GENO LLC
• Inventors: Rounbehler, David R., Fine, David H.
• Primary Examiner(s): BHAT, NINA NMN
• Application Number:
  US12/619,959
• Publication Number:
  US 20100150786A1
• Time in Patent Office: 728 Days
• Field of Search: 422/120, 422/122, 951/02, 951/20, 961/54, 961/53, 128/200.14, 128/203.12, 128/200.24
• US Class Current: 422/120
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 16/122 with dilution
• CPC Class Codes: A61M 2016/1025 the O2 concentration
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence

Abstract

A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

Claims

1. An apparatus for generating therapeutic gas including nitric oxide comprising:

a first receptacle including an inlet, an outlet, and a surface-active material coated with an antioxidant, wherein the receptacle is configured to pass a flow of gaseous nitrogen dioxide in contact with the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature;

a second receptacle including an inlet, an outlet, and a surface-active material coated with an antioxidant, wherein the receptacle is configured to pass the flow of gaseous nitrogen dioxide in contact with the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature; and

a switching valve, wherein the position of the switching valve creates a fluid connection to the first receptacle inlet or the second receptacle inlet.

2. The apparatus of claim 1 wherein the surface-active material is saturated with the aqueous solution of the antioxidant.

3. The apparatus of claim 1 wherein the surface-active material comprises a substrate that retains water.

4. The apparatus of claim 3 wherein the surface-active material comprises a silica gel.

5. The apparatus of claim 1 wherein each of the first receptacle and second receptacle comprise cartridges.

6. The apparatus of claim 1 wherein the antioxidant comprises ascorbic acid.

7. The apparatus of claim 1 wherein the antioxidant comprises tocopherol.

8. The apparatus of claim 1 further comprising a third receptacle including an inlet, an outlet, and activated alumina, wherein the inlet of the third receptacle is configured to receive flow from the first receptacle or second receptacle and fluidly communicate the flow to the outlet of the third receptacle throught the activated alumina.

9. The apparatus of claim 1 wherein each of the first receptacle and second receptacle includes a screen and glass wool adjacent to both the inlet and the outlet.

10. The apparatus of claim 1 further comprising a nitrogen source fluidly connected to the first receptacle outlet and to the second receptacle outlet.

11. The apparatus of claim 10 further comprising a second switching valve fluidly connected to the second receptacle inlet.

12. A method for delivering therapeutic nitric oxide to a mammal comprising:

diffusing nitric oxide into a gas flow;

exposing the nitric oxide to a surface-active material coated with an antioxidant to convert any nitrogen dioxide formed to nitric oxide; and

transporting the nitric oxide in a therapeutic amount to a mammal.

13. The method of claim 12, wherein the surface-active material is contained in a receptacle including an inlet, an outlet, and wherein the receptacle is configured to pass a flow of nitric oxide in contact with the surface-active material to convert the any nitrogen dioxide to nitric oxide at ambient temperature.

14. The method of claim 13, further comprising placing the receptacle near an exit of tubing lines.

15. The method of claim 13, further comprising placing the receptacle near an exit of gas plumbing lines.

16. The method of claim 13, further comprising placing the receptacle near an exit of has inhalation equipment.

17. The method of claim 13, wherein the receptacle comprises a cartridge.

18. A method for delivering therapeutic nitric oxide to a mammal comprising:

diffusing nitric oxide into a gas flow;

exposing the nitric oxide to a surface-active material coated with reducing agent to convert any nitrogen dioxide formed to nitric oxide; and

transporting the nitric oxide in a therapeutic amount to a mammal.

19. An apparatus for generating a therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal comprising:

a gas bottle having nitrogen dioxide and capable of providing a flow of gaseous nitrogen dioxide; and

a receptacle including an inlet, an outlet, and a surface-active material coated with a reducing agent,

wherein the inlet is configured to receive the flow from the gas bottle and fluidly communicate the flow to the outlet through the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature, wherein the receptacle is configured to attach to the gas bottle.

20. The apparatus of claim 19, wherein the surface-active material is saturated with an aqueous solution of the reducing agent.