Stable clozapine suspension formulation
First Claim
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1. A physicochemically stable aqueous composition for oral administration comprising:
- clozapine in suspension;
a wetting agent selected from any one or more of propylene glycol, glycerin, or polyethylene glycol;
a stabilizing agent selected from anyone or more of xanthan gum, guar gum, tragacanth gum, hydroxypropyl methylcellulose, or microcrystalline cellulose; and
a buffer, wherein the pH of the composition is maintained within the range of about 6 to about 11.
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Abstract
A physicochemically stable aqueous composition including clozapine suspension.
186 Citations
19 Claims
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1. A physicochemically stable aqueous composition for oral administration comprising:
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clozapine in suspension; a wetting agent selected from any one or more of propylene glycol, glycerin, or polyethylene glycol; a stabilizing agent selected from anyone or more of xanthan gum, guar gum, tragacanth gum, hydroxypropyl methylcellulose, or microcrystalline cellulose; and a buffer, wherein the pH of the composition is maintained within the range of about 6 to about 11. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A physicochemically stable aqueous composition for oral administration comprising:
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clozapine in suspension; a wetting agent selected from any one or more of propylene glycol, glycerin, or polyethylene glycol; polyvinyl pyrrolidone; and a buffer, wherein the pH of the composition is maintained within the range of about 6 to about 11.
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Specification