Mechanically attached medical device coatings

• US 8,057,841 B2
• Filed: 02/14/2005
• Issued: 11/15/2011
• Est. Priority Date: 02/12/2004
• Status: Expired due to Fees

• Current Assignee: University of Akron
• Original Assignee: University of Akron
• Inventors: Kataphinan, Woraphon, Smith, Daniel J., Reneker, Darrell H.
• Primary Examiner(s): Yuan; Dah-Wei
• Assistant Examiner(s): BOWMAN, ANDREW J
• Application Number:
  US10/597,899
• Publication Number:
  US 20080021545A1
• Time in Patent Office: 2,465 Days
• Field of Search: 606/29, 623/1.15, 210/636, 210/503, 210/505, 405/36, 427/2.1
• US Class Current: 427/2.1
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues
• CPC Class Codes: A61F 2002/009 for hindering or preventing attachment of biological tissue
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: Y10T 442/10 Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]

Abstract

The present invention relates to nanofibrous coatings on medical devices such a surgical mesh or stent, wherein the coating is mechanically attached to the device. The principal mechanism for attaching the coating is through causing the fibers to permeate and entangle with the substrate.

Claims

1. A method for attaching a fibrous coating to a substrate comprising the steps of:

providing a substrate;

coating a first side of the substrate with a fibrous coating; and

forcing at least one fiber through an opening in the substrate,

wherein the fibrous coating includes fibers formed from one or more polyolefins, polyethylene, polypropylene, linear poly(ethylenimine), cellulose acetate, grafted cellulosics, poly(L-lactic acid), poly(caprolactone), poly(ethyleneoxide), poly(hydroxyethylmethacrylate), poly(glycolic acid) or polyvinylpyrrolidone,

wherein the step of forcing at least a portion of the fibrous coating through said opening in the substrate is performed by pulling a substantially needle-like object through said opening in the substrate, wherein a portion of the fibrous coating is pulled through said opening by the needle-like object.

2. A method for attaching a fibrous coating to a substrate comprising the steps of:

providing a substrate;

coating a first side of the substrate with a fibrous coating; and

forcing at least one fiber through an opening in the substrate,

wherein the fibrous coating includes fibers formed from one or more polyolefins, polyethylene, polypropylene, linear poly(ethylenimine), cellulose acetate, grafted cellulosics, poly(L-lactic acid), poly(caprolactone), poly(ethyleneoxide), poly(hydroxyethylmethacrylate), poly(glycolic acid) or polyvinylpyrrolidone,

wherein the step of forcing at least a portion of the fibrous coating through said opening in the substrate is achieved by performing the additional steps of;

inserting a portion of at least one substantially needle-like object through said opening;

attaching at least one nanofiber to the substantially needle-like object; and

withdrawing the substantially needle-like object from said opening so that the at least one nanofiber is pulled through said opening.

3. A method for attaching a fibrous coating to a substrate comprising the steps of:

providing a substrate;

coating a first side of the substrate with a fibrous coating; and

forcing at least one fiber through an opening in the substrate,

wherein the fibrous coating includes fibers formed from one or more polyolefins, polyethylene, polypropylene, linear poly(ethylenimine), cellulose acetate, grafted cellulosics, poly(L-lactic acid), poly(caprolactone), poly(ethyleneoxide), poly(hydroxyethylmethacrylate), poly(glycolic acid) or polyvinylpyrrolidone;

applying a positively-charged fibrous coating to a first side of the substrate; and

applying a negatively-charged fibrous coating to a second side of the substrate.