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Oligonucleotide mediated nucleic acid recombination

  • US 8,058,001 B2
  • Filed: 09/11/2009
  • Issued: 11/15/2011
  • Est. Priority Date: 01/19/1999
  • Status: Expired due to Fees
First Claim
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1. A method of recombining homologous nucleic acids, the method comprising:

  • (i) hybridizing a chemically synthesized set of family gene shuffling oligonucleotides, wherein at least some oligonucleotides in the chemically synthesized set of family gene shuffling oligonucleotides correspond to at least one region of sequence diversity of the homologous nucleic acids; and

    ,(ii) elongating the set of family gene shuffling oligonucleotides, thereby providing a population of recombined nucleic acids.

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