Methods and compositions concerning siRNA's as mediators of RNA interference
First Claim
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1. A composition comprising isolated dsRNA, wherein the isolated dsRNA comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 11, SEQ ID NO;
12, SEQ ID NO;
13;
SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17;
SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, SEQ ID NO;
23, SEQ ID NO;
24, SEQ ID NO;
25, SEQ ID NO;
26, SEQ ID NO;
27, SEQ ID NO;
28, SEQ ID NO;
29, SEQ ID NO;
30;
SEQ ID NO;
31, and SEQ ID NO;
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Abstract
The present invention concerns an isolated siRNA of from about 5 to about 20 nucleotides that mediates RNA interference. Also disclosed are methods of reducing expression of a target gene in a cell comprising obtaining at least one siRNA of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 basepairs in length; and delivering the siRNA into the cell. The siRNAs can be chemically synthesized RNA or an analog of a naturally occurring RNA.
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Citations
19 Claims
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1. A composition comprising isolated dsRNA, wherein the isolated dsRNA comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 11, SEQ ID NO;
12, SEQ ID NO;
13;
SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17;
SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, SEQ ID NO;
23, SEQ ID NO;
24, SEQ ID NO;
25, SEQ ID NO;
26, SEQ ID NO;
27, SEQ ID NO;
28, SEQ ID NO;
29, SEQ ID NO;
30;
SEQ ID NO;
31, and SEQ ID NO;
32. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- 11, SEQ ID NO;
Specification
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Current AssigneeApplied Biosystems LLC (Thermo Fisher Scientific Incorporated)
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Original AssigneeApplied Biosystems LLC (Thermo Fisher Scientific Incorporated)
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InventorsKrebs, Joseph, Ford, Lance P.
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Primary Examiner(s)WHITEMAN, BRIAN A
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Application NumberUS12/484,948Publication NumberTime in Patent Office883 DaysField of Search514/44.AUS Class Current514/44.ACPC Class CodesC12N 15/111 General methods applicable ...C12N 15/1137 against enzymes viral enzym...C12N 2310/14 interfering N.A.C12N 2330/30 chemically synthesisedC12Y 102/01012 Glyceraldehyde-3-phosphate ...C12Y 502/01008 Peptidylprolyl isomerase (5...
