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Glycodendrimers having biological activity

  • US 8,058,344 B2
  • Filed: 03/18/2003
  • Issued: 11/15/2011
  • Est. Priority Date: 04/19/2002
  • Status: Expired due to Fees
First Claim
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1. A pharmaceutical formulation comprising a 3.5 generation glycodendrimer of an anion carboxylic terminated poly(amidoamine) core and monosaccaride linked such that a carboxy group on the core forms an amide bond with a nitrogen on the monosaccharide, said glycodendrimer selected from the group consisting of:

  • poly(amidoamine)-glucosamine,poly(amidoamine)-glucosamine sulfate; and

    a combination thereofwherein the amount of glucosamine monosaccharide linked to the dendrimer core expressed as a percentage of converted carboxylic acid groups is in the range 1.5% to 10.1% and wherein the amount of glucosamine sulfate monosacharide linked to the dendrimer core expressed as a percentage of converted carboxylic acid groups is 6% or 7%.

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