Glycodendrimers having biological activity
First Claim
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1. A pharmaceutical formulation comprising a 3.5 generation glycodendrimer of an anion carboxylic terminated poly(amidoamine) core and monosaccaride linked such that a carboxy group on the core forms an amide bond with a nitrogen on the monosaccharide, said glycodendrimer selected from the group consisting of:
- poly(amidoamine)-glucosamine,poly(amidoamine)-glucosamine sulfate; and
a combination thereofwherein the amount of glucosamine monosaccharide linked to the dendrimer core expressed as a percentage of converted carboxylic acid groups is in the range 1.5% to 10.1% and wherein the amount of glucosamine sulfate monosacharide linked to the dendrimer core expressed as a percentage of converted carboxylic acid groups is 6% or 7%.
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Abstract
The present invention relates to new anionic glycodendrimers having new biological activity, processes for preparing them and their use in medicine including veterinary medicine.
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Citations
3 Claims
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1. A pharmaceutical formulation comprising a 3.5 generation glycodendrimer of an anion carboxylic terminated poly(amidoamine) core and monosaccaride linked such that a carboxy group on the core forms an amide bond with a nitrogen on the monosaccharide, said glycodendrimer selected from the group consisting of:
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poly(amidoamine)-glucosamine, poly(amidoamine)-glucosamine sulfate; and a combination thereof wherein the amount of glucosamine monosaccharide linked to the dendrimer core expressed as a percentage of converted carboxylic acid groups is in the range 1.5% to 10.1% and wherein the amount of glucosamine sulfate monosacharide linked to the dendrimer core expressed as a percentage of converted carboxylic acid groups is 6% or 7%. - View Dependent Claims (2, 3)
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Specification
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Current AssigneeImperial Innovations Limited (Imperial College London)
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Original AssigneeImperial Innovations Limited (Imperial College London)
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InventorsShaunak, Sunil, Gianasi, Elisabetta, Duncan, Ruth
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Primary Examiner(s)Anderson, James D
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Assistant Examiner(s)Baek, Bong-Sook
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Application NumberUS10/511,317Publication NumberTime in Patent Office3,164 DaysField of SearchNoneUS Class Current525/54.2CPC Class CodesA61K 47/595 Polyamides, e.g. nylon poly...A61P 1/04 for ulcers, gastritis or re...A61P 17/00 Drugs for dermatological di...A61P 19/02 for joint disorders, e.g. a...A61P 29/00 Non-central analgesic, anti...A61P 31/04 Antibacterial agentsA61P 35/04 specific for metastasisA61P 37/06 Immunosuppressants, e.g. dr...
