Multiplexed photonic membranes and related detection methods for chemical and/or biological sensing applications

• US 8,059,924 B1
• Filed: 09/08/2008
• Issued: 11/15/2011
• Est. Priority Date: 09/13/2007
• Status: Active Grant

• Current Assignee: Lawrence Livermore National Security LLC (Government of the United States of America)
• Original Assignee: Lawrence Livermore National Security LLC (Government of the United States of America)
• Inventors: Letant, Sonia E., Bond, Tiziana C.
• Primary Examiner(s): MERLINO, AMANDA H
• Application Number:
  US12/206,337
• Publication Number:
  US 20090244532A1
• Time in Patent Office: 1,163 Days
• Field of Search: 385/122, 385/129, 385/130, 385/131, 385/132, 385/14, 385/141, 385/6, 385/12, 356/244, 356/39, 356/40, 356/41, 356/42, 600/310, 600/364, 600/407, 398/79
• US Class Current: 385/12
• CPC Class Codes: B82Y 20/00 Nanooptics, e.g. quantum optics or photonic crystals
• CPC Class Codes: G01N 2021/7763 Sample through flow
• CPC Class Codes: G01N 2021/7776 Index
• CPC Class Codes: G01N 21/774 the reagent being on a grating or periodic structure
• CPC Class Codes: G02B 1/005 made of photonic crystals or photonic band gap materials photonic band-gap structures or photonic lattices in integrated optics G02B6/1225; photonic band-gap structures or photonic lattices in optical fibres G02B6/02295
• CPC Class Codes: G02B 6/1225 comprising photonic band-gap structures or photonic lattices

Abstract

Photonic detection systems and methods are shown. A flow through photonic membrane is provided with pores which are distributed along multiple regions. The pores of one region have walls to which a first type of target specific anchor can be attached, while pores of another region have walls to which a second type of target specific anchor can be attached. An additional region of pores without anchors can be provided, so that optical detection occurs differentially. A stack of photonic membranes is also provided. The diameter of the pores of one photonic membrane is larger than the diameter of the pores of another photonic membrane, thus allowing also determination of the size of a target organism flown through the stack of membranes.

Claims

1. A photonic detection system comprising:

a photonic membrane with through pores, the through pores having inner walls to which chemical or biological target specific anchors are adapted to be attached;

an optical input to the photonic membrane; and

an optical output detecting arrangement connected with the photonic membrane,

wherein the through pores are distributed on the photonic membrane along multiple regions of through pores, through pores pertaining to a first region having inner walls to which a first type of chemical or biological target specific anchor is attached, through pores pertaining to a second region having inner walls to which a second type of chemical or biological target specific anchor is attached, and so on,

wherein the photonic membrane comprises an additional region of through pores to which no chemical or biological target specific anchors are attached, and

wherein measurement of a detection output of the photonic detection system occurs differentially, by subtraction of a detection output of the additional region of through pores from a detection output of each region of through pores.

2. The system of claim 1, wherein the optical input to the photonic membrane comprises a plurality of optical input lines, one for each region of through pores.

3. The system of claim 1, wherein the optical output detecting arrangement comprises a plurality of detectors, one for each region of through pores.

4. The system of claim 1, wherein the optical input is a laser light.

5. The system of claim 1, wherein the optical detecting arrangement is a multichannel detector.

6. The system of claim 1, wherein the optical detecting arrangement is connected with a processing unit downstream of the photonic membrane.

7. The system of claim 6, wherein the processing unit is a portable computer.

8. The system of claim 1, wherein the photonic membrane is a silicon photonic membrane.

9. The system of claim 1, wherein the multiple regions of through pores are shaped differently from each other.

10. The system of claim 1, wherein each region of through pores is selected from the group consisting of:

a line of through pores with a ridge geometry, a perfect photonic crystal comprising an array of through pores, and a photonic crystal comprising an array of through pores and a defect.

11. The system of claim 10, wherein the defect is selected from the group consisting of:

a pore with a different diameter or shape than the remaining through pores of the array, and a removed pore.