Analyte sensing biointerface
First Claim
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1. A glucose sensor configured for implantation in a host, comprising:
- a biocompatible matrix comprising a plurality of passageways distributed throughout the biocompatible matrix, each of the plurality of passageways having interior surfaces;
a working electrode distributed throughout at least some of the interior surfaces of the plurality of passageways; and
a membrane disposed on the working electrode and distributed within the interior surfaces of the plurality of passageways, and wherein the membrane is configured to control a rate of diffusion of glucose through the membrane, and wherein the membrane comprises an enzyme configured to react with glucose to produce a species configured to electrochemically react at the working electrode.
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Abstract
Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
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Citations
16 Claims
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1. A glucose sensor configured for implantation in a host, comprising:
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a biocompatible matrix comprising a plurality of passageways distributed throughout the biocompatible matrix, each of the plurality of passageways having interior surfaces; a working electrode distributed throughout at least some of the interior surfaces of the plurality of passageways; and a membrane disposed on the working electrode and distributed within the interior surfaces of the plurality of passageways, and wherein the membrane is configured to control a rate of diffusion of glucose through the membrane, and wherein the membrane comprises an enzyme configured to react with glucose to produce a species configured to electrochemically react at the working electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A lucose sensor configured for implantation in a host, comprising:
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a biocompatible matrix comprising a plurality of fibers and a plurality of passageways having interior surfaces; and a working electrode comprising at least one electroactive surface configured to detect an analyte concentration, the at least one electroactive surface located on a portion of an interior surface of at least one of the plurality of passageways, wherein at least one of the plurality of fibers comprises an electrode core that forms an electroactive surface of the working electrode. - View Dependent Claims (14)
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15. A glucose sensor configured for implantation in a host, comprising:
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a biocompatible matrix comprising a plurality of passageways having interior surfaces; and a working electrode comprising at least one electroactive surface configured to detect an analyte concentration, the at least one electroactive surface located on a portion of an interior surface of at least one of the plurality of passageways, wherein the at least one of the plurality of passageways extends through a conductive layer, wherein an interface formed between the interior surface of at least one passageway and the conductive layer forms an electroactive surface of the working electrode. - View Dependent Claims (16)
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Specification