Device for determining thoracic impedance

• US 8,060,196 B2
• Filed: 12/02/2005
• Issued: 11/15/2011
• Est. Priority Date: 12/02/2004
• Status: Expired due to Fees

• Current Assignee: Biotronik SE & Company KG
• Original Assignee: Biotronik CRM Patent AG (Biotronik SE & Company KG)
• Inventors: Lippert, Michael, Czygan, Gerald
• Primary Examiner(s): Hindenburg; Max
• Assistant Examiner(s): EISEMAN, ADAM JARED
• Application Number:
  US11/293,398
• Publication Number:
  US 20060135886A1
• Time in Patent Office: 2,174 Days
• Field of Search: 600/547, 324/600, 324/602, 324/603, 324/604, 324/606, 324/609
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content

Abstract

An electromedical implant includes a measuring signal generator, an impedance measuring unit to determine the impedance of human or animal tissue, a control unit which, for controlling the measuring signal generator and the impedance measuring unit, is at least indirectly connected to the measuring signal generator and to the impedance measuring unit, as well as an electrode arrangement comprising at least two electrodes which can be directly or indirectly connected or at least temporarily connected to the measuring signal generator and to the impedance measuring unit, or to a connection for such an electrode arrangement. The measuring signal generator is designed to generate and emit a current pulse or a series of current pulses, and the control unit is designed at a specific point in time to cause the measuring signal generator (to generate and emit a current pulse, and to cause the impedance measuring unit to measure the voltage that is present between the electrodes connected to the measuring signal generator and the impedance measuring unit after the passing of at least two time periods of different length that start with commencement of the current pulse being emitted and end before the end of emitting the current pulse, and to issue a voltage value which in each case represents the measured voltage.

Claims

1. An electromedical implant comprising at least a measuring signal generator;

an impedance measuring unit to determine the impedance of human or animal tissue;

a control unit which, for controlling the measuring signal generator and the impedance measuring unit, is at least indirectly connected to the measuring signal generator and the impedance measuring unit;

as well as an electrode arrangement comprising at least two electrodes which can be directly or indirectly connected or at least temporarily connected to the measuring signal generator and to the impedance measuring unit, or to a connection for such an electrode arrangement;

wherein;

the measuring signal generator is designed to generate and emit first and second current pulses of variable pulse duration;

and wherein the control unit is programmed at least at first and second different points in time to cause the measuring signal generator to generate and emit the first current pulse and the second current pulse, so that emission of the first current pulse is finished before emission of the second current pulse starts, and the pulse duration of the emitted first and second current pulses are different;

and to cause the impedance measuring unit to measure the voltage that is present between the electrodes connected to the measuring signal generator and the impedance measuring unit

by measuring a first voltage at the beginning of a specific period of time that ends when emitting the first current pulse ends, and to issue the first voltage as a voltage value which represents the measured first voltage; and

by measuring a second voltage at the beginning of said specific period of time that ends when emitting the second current pulse ends, and to issue the second voltage as a voltage value which represents the measured second voltage.

2. The electromedical implant according to claim 1, wherein the control unit is programmed to determine a value which represents a difference between the first and second voltage values measured by the impedance measuring unit during the first and second current pulses of different duration emitted by the measuring signal generator and to issue this difference as a voltage difference value.

3. The electromedical implant according to claim 2, wherein:

the control unit is programmed to cause the measuring signal generator to generate and emit a current pulse at more than two different points in time so that emission of an earlier current pulse ends before emission of an immediately subsequent current pulse starts, and the pulse durations of the emitted earlier and immediately subsequent current pulses differ from each other;

and to cause the impedance measuring unit to measure the voltage that is present between the electrodes that are connected to the measuring signal generator and to the impedance measuring unit by measuring a pulse voltage at the beginning of a specific period of time that ends when emission of the respective current pulse ends; and

and wherein furthermore, the control unit is programmed, for each of the points in time of causing a voltage reading to be taken depending on a first parameter U₀ and/or a second parameter τ

, to determine a multitude of compensating-curve values U_A which are calculated according to the formula

U_A=U₀*(1−

e<sup>−

t/τ</sup>

)

wherein e denotes Euler'"'"'s integral and t denotes the duration between the point in time of commencement of emission of the current pulse, during which emission the control unit has caused the voltage reading, in relation to which the multitude of compensating-curve values U_A are to be determined, and the point in time of causing the voltage reading, in relation to which the multitude of compensating-curve values U_A are to be determined;

in relation to a multitude of combinations of a value of the first parameter U₀ and/or a value of the second parameter τ

to determine the sum of the squares of the differences of all voltage values measured during the more than two current pulses, and of the compensating-curve value U_A calculated in relation to each voltage value according to the respective combination of a value of the first parameter U₀ and/or of a value of the second parameter τ

;

as well as by selecting the lowest sum to issue a combination of a value of the first parameter U₀ and/or of a value of the second parameter τ and

to issue it as a result parameter combination.

4. The electromedical implant according to claim 2, wherein:

the control unit is programmed at more than two different points in time to cause the measuring signal generator to generate and emit a current pulse so that emission of the first current pulse ends before commencement of emission of the second current pulse, and so that the pulse durations of the emitted current pulses differ from each other;

and to cause the impedance measuring unit to measure the voltage that is present between the electrodes that are connected to the measuring signal generator and the impedance measuring unit

by measuring a first voltage at the beginning of a specific period of time which ends when emission of the first current pulse ends; and

by measuring a second voltage at the beginning of said specific period of time that ends when emission of the second current pulse ends;

and wherein furthermore, the control unit is programmed to determine the coefficients of a polynomial which acts as a compensating curve, in relation to which polynomial the sum of the squares of the differences of all voltage values measured during the more than two current pulses and the values of the function of the polynomial for the points in time of causing a voltage reading from the point in time of the beginning of emission of the respective current pulse is minimal, and to issue them as a result coefficient.

5. The electromedical implant according to claim 4, wherein:

the measuring signal generator is adapted to generate current pulses of variable pulse duration, wherein the pulse duration is at least a first duration and at the longest a second duration;

and wherein the control unit is programmed to cause the measuring signal generator to emit a larger number of current pulses of comparatively short pulse duration than of current pulses of comparatively longer pulse duration.

6. The electromedical implant according to claim 5, wherein:

the control unit is programmed to determine a value that represents a difference between the compensating-curve values U_A of the result parameter combination or of the result coefficients in relation to the durations t of the current pulses with the longest and shortest pulse durations and to issue said value as a voltage difference value.

7. The electromedical implant according to claim 6, wherein:

the measuring signal generator is adapted to generate biphasal current pulses.

8. The electromedical implant according to claim 7, wherein:

the impedance measuring unit is programmed to take impedance readings during emission of differently polarised segments of a biphasal current pulse through the measuring signal generator;

and wherein the control unit is programmed to relate the values obtained in this way and to determine and issue a differential value obtained, which value represents a difference between two values obtained during emission of differently polarised segments of a biphasal current pulse.

9. The electromedical implant according to claim 1, wherein:

the electromedical implant comprises more than two electrodes or can be connected to more than two electrodes;

and wherein the impedance measuring unit is adapted to be connected to a selectable electrode and to a fixed or selectable electrode, and to measure a voltage that is present between these electrodes.

10. The electromedical implant according to claim 9, wherein:

the electromedical implant comprises more than two electrodes or can be connected to more than two electrodes;

and wherein the measuring signal generator is adapted to be connected to a selectable electrode and a fixed or selectable electrode.

11. The electromedical implant according to claim 10, wherein:

the control unit is programmed in relation to several different combinations of two electrodes that are connected or adapted to be connected with the impedance measuring unit and the measuring signal generator to emit a current pulse or a sinusoidal current, and to cause the impedance measuring unit to measure the voltage that is present between the respective combination of two electrodes and to calculate and issue an average value of the voltage values that have been determined in this way and that represent the measured voltages.

12. The electromedical implant according to claim 11, wherein:

the electromedical implant is a cardiac pacemaker, cardioverter or defibrillator.

13. The electromedical implant according to claim 12, wherein:

the electromedical implant comprises a cardiac activity detector which is designed to register the cardiac cycle of a patient and at a defined point in time within a cardiac cycle, to issue a signal to the control unit;

and wherein the control unit is programmed, after receiving a signal from the cardiac activity detector, to cause the measuring signal generator to generate a current pulse or a measuring signal and to emit said current pulse or measuring signal by way of at least one electrode.

14. The electromedical implant according to claim 13, wherein:

the electromedical implant comprises a respiratory activity detector which is designed to register the respiratory cycle of a patient and at a defined point in time within a respiratory cycle to issue a signal to the control unit;

and wherein the control unit is programmed, after receiving a signal from the cardiac activity detector, to cause the measuring signal generator to generate a current pulse or a measuring signal and to emit said current pulse or measuring signal by way of at least one electrode.

15. The electromedical implant according to claim 14, wherein:

the electromedical implant is programmed to take series of impedance readings;

and wherein the control unit is programmed to determine the average value of the readings obtained in a series of impedance readings and to issue it as a resulting value.

16. The electromedical implant according to claim 15, wherein:

the electromedical implant is programmed to take series of impedance readings;

and wherein the control unit is programmed to determine the median of the readings obtained in a series of impedance readings and to issue it as a resulting value.

17. The electromedical implant according to claim 16, wherein:

the electromedical implant comprises a wireless data transmission interface;

and wherein the wireless data transmission interface is programmed to transmit to a home monitoring service center one or several of the parameters, determined or issued by the control unit, such as the voltage difference value, average value, value of the first parameter U₀, value of the second parameter τ and

amplitude difference value and/or one or several of the voltage values or amplitude values determined by the impedance measuring unit, by way of the wireless data transmission interface directly or indirectly as patient data.

18. A system comprising at least

an electromedical implant according to claim 17

and at least one of a patient device and a home monitoring service center;

wherein the electromedical implant and the patient device can be connected to each other by way of wireless data transmission interfaces, and the patient device and the home monitoring service center can be connected to each other by way of a wireless or a wire-bound data transmission interface.

19. The system according to claim 18, wherein:

the patient device or the home monitoring service center is programmed to store the patient data received by the electromedical implant and to calculate short-term and long-term average values of individual patient data.

20. The system according to claim 19, wherein:

the patient device or the home monitoring service centre are programmed to compare received patient data with the calculated short-term and long-term average values.

21. The system according to claim 20, wherein:

the patient device or the home monitoring service centre are programmed to display any deviations between the short-term and long-term average values and the patient data compared with the short-term and long-term average values.