Methods and systems of treating ischemia pain in visceral organs

• US 8,060,209 B2
• Filed: 01/23/2009
• Issued: 11/15/2011
• Est. Priority Date: 01/25/2008
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Jaax, Kristen N., Whitehurst, Todd K., DiGiore, Andrew
• Primary Examiner(s): Manuel; George
• Application Number:
  US12/359,144
• Publication Number:
  US 20090192570A1
• Time in Patent Office: 1,026 Days
• Field of Search: 607/46
• US Class Current: 607/46
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36071 Pain

Abstract

Methods and systems of treating a patient with ischemia pain include providing a stimulator, configuring one or more stimulation parameters to treat ischemia pain in a visceral organ, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to treat ischemia pain with the stimulator in accordance with the one or more stimulation parameters, and applying the stimulus with the stimulator to one or more stimulation sites in accordance with the one or more stimulation parameters.

Claims

1. A method of treating a patient with ischemia pain, comprising:

providing a stimulator;

configuring one or more stimulation parameters to treat ischemia pain in a visceral organ, wherein said visceral organ comprises at least one or more of a pancreas, a duodenum, a small intestine, a colon, a liver, a spleen, a kidney, an adrenal glands, a stomach, an appendix, and a gall bladder;

programming said stimulator with said one or more stimulation parameters;

generating a stimulus configured to treat said ischemia pain with said stimulator in accordance with said one or more stimulation parameters; and

applying said stimulus with said stimulator to a stimulation site within said patient;

wherein said stimulation site comprises at least one or more of a vascular tissue of said visceral organ and a nerve innervating said vascular tissue of said visceral organ.

2. The method of claim 1, wherein said stimulation site comprises at least one or more of an aorta, a nerve innervating said aorta, a celiac trunk, a spinal cord level, a splenic artery, a nerve innervating said splenic artery, a splenic vein, a nerve innervating said splenic vein, a portal vein, a nerve innervating said portal vein, a hepatic artery, a nerve innervating said hepatic artery, a gastroduodenal artery, a nerve innervating said gastroduodenal artery, a superior mesenteric artery, a nerve innervating said superior mesenteric artery, a superior mesenteric vein, a nerve innervating said superior mesenteric vein, a pancreaticoduodenal artery, a nerve innervating said pancreaticoduodenal artery, a blood vessel associated with said visceral organ, and a nerve innervating said blood vessel.

3. The method of claim 1, wherein said stimulus is configured to induce dilation of said vascular tissue.

4. The method of claim 1, wherein said stimulator is coupled to one or more electrodes, and wherein said stimulus comprises a stimulation current delivered via said electrodes.

5. The method of claim 1, wherein said stimulus comprises an infusion of one or more drugs at said stimulation site.

6. The method of claim 1, wherein said ischemia pain is associated with pancreatitis.

7. The method of claim 1, further comprising sensing at least one indicator related to said ischemia pain and using said at least one sensed indicator to adjust one or more of said stimulation parameters.

8. The method of claim 7, wherein said indicator comprises at least one or more of a neurotransmitter level, a user input, a circumference change in vascular tissues, a detection of blood flow, a change in blood oxygenation, a change in pH, a change in hormone concentration, a detected stomach activity, a circumference change in a duodenum, a pyloric sphincter contraction, a detection of food passing through the gastrointestinal tract, a change in pH, a sound, a contraction of exocrine tissue, a pressure change in a bile duct, a pressure change in a pancreatic duct, a pressure change in an ampulla, and a pressure change in a duodenum.

9. The method of claim 7, further comprising sensing said at least one indicator with at least one or more of a patient feedback sensor, a hormonal sensor, a chemical sensor, a piezoelectric sensor, a strain gauge, an optical sensor, a pH sensor, an auditory sensor, and a pressure sensor.

10. A method of treating ischemia pain, said method comprising:

implanting a stimulator at least partially within a patient;

configuring one or more stimulation parameters to treat ischemia pain in a visceral organ, wherein said visceral organ comprises at least one or more of a pancreas, a duodenum, a small intestine, a colon, a liver, a spleen, a kidney, an adrenal glands, a stomach, an appendix, and a gall bladder;

programming said stimulator with said one or more stimulation parameters;

generating a stimulation current configured to treat said ischemia pain with said stimulator in accordance with said one or more stimulation parameters; and

applying said stimulation current with said implanted stimulator to a stimulation site within said patient;

wherein said stimulation site comprises at least one or more of a vascular tissue of said visceral organ and a nerve innervating said vascular tissue of said visceral organ.

11. The method of claim 10, wherein said stimulation site comprises at least one or more of an aorta, a nerve innervating said aorta, a celiac trunk, a spinal cord level, a splenic artery, a nerve innervating said splenic artery, a splenic vein, a nerve innervating said splenic vein, a portal vein, a nerve innervating said portal vein, a hepatic artery, a nerve innervating said hepatic artery, a gastroduodenal artery, a nerve innervating said gastroduodenal artery, a superior mesenteric artery, a nerve innervating said superior mesenteric artery, a superior mesenteric vein, a nerve innervating said superior mesenteric vein, a pancreaticoduodenal artery, a nerve innervating said pancreaticoduodenal artery, a blood vessel associated with said visceral organ, and a nerve innervating said blood vessel.

12. The method of claim 10, wherein said stimulus is configured to induce dilation of said vascular tissue.

13. The method of claim 10, further comprising sensing at least one indicator related to said ischemia pain and using said at least one sensed indicator to adjust one or more of said stimulation parameters.

14. The method of claim 13, wherein said indicator comprises at least one or more of a neurotransmitter level, a user input, a circumference change in vascular tissues, a detection of blood flow, a change in blood oxygenation, a change in pH, a change in hormone concentration, a detected stomach activity, a circumference change in a duodenum, a pyloric sphincter contraction, a detection of food passing through the gastrointestinal tract, a change in pH, a sound, a contraction of exocrine tissue, a pressure change in a bile duct, a pressure change in a pancreatic duct, a pressure change in an ampulla, and a pressure change in a duodenum.

15. The method of claim 14, further comprising sensing said at least one indicator with at least one or more of a patient feedback sensor, a hormonal sensor, a chemical sensor, a piezoelectric sensor, a strain gauge, an optical sensor, a pH sensor, an auditory sensor, and a pressure sensor.

16. A system for treating a patient with ischemia pain, said system comprising:

a stimulator configured to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat ischemia pain in a visceral organ, wherein said visceral organ comprises at least one or more of a pancreas, a duodenum, a small intestine, a colon, a liver, a spleen, a kidney, an adrenal glands, a stomach, an appendix, and a gall bladder;

a programmable memory unit in communication with said stimulator and programmed to store said one or more stimulation parameters to at least partially define said stimulus such that said stimulus is configured to treat said ischemia pain; and

means, operably connected to said stimulator, for applying said stimulus to a stimulation site within said patient;

wherein said stimulation site comprises at least one or more of a vascular tissue of said visceral organ and a nerve innervating said vascular tissue of said visceral organ.

17. The system of claim 16, wherein said means for applying said at least one stimulus comprises one or more electrodes, and wherein said stimulus comprises a stimulation current delivered via said electrodes.

18. The system of claim 16, further comprising a sensor operably connected to said stimulator.

19. The system of claim 16, wherein said stimulus is configured to induce dilation of said vascular tissue.