Apparatus for determining association variables

• US 8,062,219 B2
• Filed: 07/31/2006
• Issued: 11/22/2011
• Est. Priority Date: 07/10/2004
• Status: Expired due to Fees

• Current Assignee: Trigeminal Solutions, Inc.
• Original Assignee: Trigeminal Solutions
• Inventors: Newman, Lawrence, Lanckriet, Gert, Stupp, Steven Elliot
• Primary Examiner(s): Yao; Sam
• Assistant Examiner(s): SORIANO, BOBBY GILES
• Application Number:
  US11/496,755
• Publication Number:
  US 20060270918A1
• Time in Patent Office: 1,940 Days
• Field of Search: None
• US Class Current: 600/300
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: G06F 17/18 for evaluating statistical data , e.g. average values, frequency distributions, probability functions, regression analysis forecasting specially adapted for a specific administrative, business or logistic context G06Q10/04
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 20/60 relating to nutrition control, e.g. diets
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

An apparatus, and related method, for determining one or more association variables is described. The apparatus includes at least one processor, at least one memory, and at least one program module stored in the memory configured to be executed by the processor. The program module includes instructions for selecting a subset of temporal onsets in a set of temporal onsets, instructions for determining a statistical relationship between the subset of temporal onsets and a pattern of occurrence of a variable, and instructions for identifying the variable as a migraine variable in accordance with the statistical relationship. The subset of temporal onsets includes one or more onsets corresponding to one or more migraines experienced by at least one individual, and the set of temporal onsets includes the subset of temporal onsets and one or more temporal onsets corresponding to one or more additional headaches experienced by at least the one individual.

Claims

1. An apparatus to determine one or more migraine triggers associated with migraines, comprising:

at least one processor;

at least one memory configured to store information associated with a set of temporal onsets that is associated with headaches experienced by at least one individual, and information associated with a pattern of occurrence of a variable associated with at least the one individual; and

at least one program module, the program module stored in the memory and configurable to be executed by the processor, the program module including;

instructions for selecting a subset of temporal onsets in the set of temporal onsets based on one or more characteristics of different types of headaches, wherein the different types of headaches include migraine and recurrence migraine, wherein the subset of temporal onsets includes one or more onsets corresponding to one or more migraines in the headaches experienced by at least the one individual, wherein the set of temporal onsets includes the subset of temporal onsets and one or more temporal onsets corresponding to one or more additional headaches in the headaches experienced by at least the one individual, wherein the one or more additional headaches include one or more recurrence migraines, wherein the one or more characteristics of recurrence migraine include that a given recurrence migraine corresponds to a given temporal onset in a given group of two or more temporal onsets in the set of temporal onsets that is within a predetermined time interval after an initial temporal onset in the given group of two or more temporal onsets, and wherein the group of two or more temporal onsets can be associated with a single migraine attack;

instructions for determining a statistical relationship between the subset of temporal onsets and the pattern of occurrence of the variable in an underdetermined problem in which there are more variables than temporal onsets in the set of temporal onsets, wherein a severity of the underdetermined problem is increased by excluding the one or more temporal onsets corresponding to one or more additional headaches; and

instructions for identifying the variable as a migraine trigger in accordance with the statistical relationship.

2. The apparatus of claim 1, wherein the statistical relationship includes contributions from presence and absence information in the pattern of occurrence of the variable.

3. The apparatus of claim 1, wherein the one or more additional headaches include one or more tension headaches.

4. The apparatus of claim 1, further comprising instructions for excluding at least one of the temporal onsets in the set of temporal onsets from the subset of temporal onsets due to missing data in the pattern of occurrence of the variable that was not reported by at least the one individual.

5. The apparatus of claim 1, wherein the pattern of occurrence of the variable is during a set of time intervals, and wherein a respective time interval in the set of time intervals precedes a corresponding respective temporal onset in the subset of temporal onsets.

6. The apparatus of claim 5, wherein time intervals in the set of time intervals are offset in time from temporal onsets in the subset of temporal onsets.

7. The apparatus of claim 1, the program module further including instructions for receiving information including the set of temporal onsets and the pattern of occurrence of the variable.

8. The apparatus of claim 1, the program module further including instructions for providing recommendations to one or more individuals in accordance with the migraine variable.

9. The apparatus of claim 1, wherein the determining uses a non-parametric statistical analysis technique selected from a group consisting of a chi-square analysis technique, a log-likelihood ratio analysis technique and a Fisher'"'"'s exact probability analysis technique.

10. The apparatus of claim 1, wherein the determining uses a supervised learning technique selected from a group consisting of a support vector machines (SVM) analysis technique, a Lasso analysis technique and a classification and regression tree (CART) analysis technique.

11. The apparatus of claim 1, wherein the predetermined time interval is less than or equal to 24 hours.

12. The apparatus of claim 1, the program module further including instructions for determining statistical relationships for a plurality of variables in the underdetermined problem.

13. The apparatus of claim 12, the program module further including instructions for determining a first ranking of the plurality of variables based on at least a subset of the statistical relationships, wherein the first ranking is based on the number of occurrences of the variables in the at least the subset of the statistical relationships.

14. The apparatus of claim 13, the program module further including instructions for subtracting a second ranking from the first ranking, wherein the second ranking corresponds to a background signal.

15. The apparatus of claim 1, wherein a respective entry in a pattern of occurrence of the variable is considered present if the respective entry approximately exceeds a threshold.

16. The apparatus of claim 1, wherein the migraine trigger at least in part induces a migraine in at least the one individual if at least the one individual is exposed to the migraine trigger.

17. The apparatus of claim 16, the program module further including instructions for identifying one or more additional migraine triggers of at least the one individual based on the presence of the identified migraine trigger in one or more groups of migraine triggers that were previously determined for one or more other individuals.

18. The apparatus of claim 1, wherein entries in the pattern of occurrence of the variable during time intervals associated with ongoing durations of each of the migraines corresponding to the subset of temporal onsets are excluded when the statistical relationship is determined.

19. A non-transitory computer-program product for use in conjunction with a computer system, the computer-program product comprising a computer-readable storage medium and a computer-program mechanism embedded therein for determining one or more migraine triggers associated with migraines, the computer-program mechanism including:

instructions for selecting a subset of temporal onsets in a set of temporal onsets that is associated with headaches experienced by at least one individual based on one or more characteristics of different types of headaches, wherein the different types of headaches include migraine and recurrence migraine, wherein the subset of temporal onsets includes one or more onsets corresponding to one or more migraines in the headaches experienced by at least the one individual, wherein the set of temporal onsets includes the subset of temporal onsets and one or more temporal onsets corresponding to one or more additional headaches in the headaches experienced by at least the one individual, wherein the one or more additional headaches include one or more recurrence migraines, wherein the one or more characteristics of recurrence migraine include that a given recurrence migraine corresponds to a given temporal onset in a given group of two or more temporal onsets in the set of temporal onsets that is within a predetermined time interval after an initial temporal onset in the given group of two or more temporal onsets, and wherein the group of two or more temporal onsets can be associated with a single migraine attack;

instructions for determining a statistical relationship between the subset of temporal onsets and a pattern of occurrence of a variable associated with at least the one individual in an underdetermined problem in which there are more variables than temporal onsets in the set of temporal onsets, wherein a severity of the underdetermined problem is increased by excluding the one or more temporal onsets corresponding to one or more additional headaches; and

instructions for identifying the variable as a migraine trigger in accordance with the statistical relationship.

20. An apparatus to determine one or more migraine triggers associated with migraines, comprising:

means for computing;

means for storing information associated with a set of temporal onsets that is associated with headaches experienced by at least one individual, and information associated with a pattern of occurrence of a variable associated with at least the one individual; and

at least one program module mechanism, the program module mechanism stored in at least the means for storing and configurable to be executed by at least a computing means, at least the program module mechanism including;

instructions for selecting a subset of temporal onsets in the set of temporal onsets based on one or more characteristics of different types of headaches, wherein the different types of headaches include migraine and recurrence migraine, wherein the subset of temporal onsets includes one or more onsets corresponding to one or more migraines in the headaches experienced by at least the one individual, wherein the set of temporal onsets includes the subset of temporal onsets and one or more temporal onsets corresponding to one or more additional headaches in the headaches experienced by at least the one individual, wherein the one or more additional headaches include one or more recurrence migraines, wherein the one or more characteristics of recurrence migraine include that a given recurrence migraine corresponds to a given temporal onset in a given group of two or more temporal onsets in the set of temporal onsets that is within a predetermined time interval after an initial temporal onset in the given group of two or more temporal onsets, and wherein the group of two or more temporal onsets can be associated with a single migraine attack;

instructions for determining a statistical relationship between the subset of temporal onsets and the pattern of occurrence of the variable in an underdetermined problem in which there are more variables than temporal onsets in the set of temporal onsets, wherein a severity of the underdetermined problem is increased by excluding the one or more temporal onsets corresponding to one or more additional headaches; and

instructions for identifying the variable as a migraine trigger in accordance with the statistical relationship.